PhD, Pharmaceutical Sciences
Visiting Researcher, Department of Biomedical Chemistry, School of International Health, Graduate School of Medicine, The University of Tokyo.
I was born and lived 21 years in Brazil, an endemic country for Chagas disease and Leishmaniasis. I studied at the Faculty of Pharmacy from Universidade Federal do Rio Grande do Norte. In 2000, I came to Japan and under the support of Mombukagakusho Scholarship I obtained Master and PhD degree in Pharmaceutical Sciences at Graduate School of Pharmaceutical Sciences, The University of Tokyo. During my Master and Doctoral course I have analyzed the biochemical and structural biological properties of dihydroorotate dehydrogenase, a potential drug target from Trypanosoma cruzi involved in pyrimidine de novo biosynthesis. In 2005, I moved to Graduate School of Medicine, The University of Tokyo supported by Postdoctoral Fellowships for Foreign Researchers (JSPS) to start research in structural biology and drug design targeting the unique energy metabolism found in Trypanosomatids and Helminthes. Since 2007, I become Assistant Professor of Department of Biomedical Chemistry from Graduate School of Medicine at The University of Tokyo to research molecular and biochemical parasitology and drug design targeting enzymes involved in microaerophilic mitochondrial metabolism from protozoan parasites and helminthes. I have expertise in the field of biochemistry, parasite metabolism, structural biology and drug design.
I worked as part-time lecturer for practical class in biophysics at Teikyo University, between 2002 and 2005. I was also in charge of practical class in biochemistry at School of International Health, The University of Tokyo, from 2007 to 2016. At TMGH, Nagasaki University, I will be teaching part of Basic Human Biology coordinated by Prof. Kita and Prof. Kamiya.
Based in keywords such as “Parasite”, “Mitochondria”, “Host Environment Adaptation”, “Ubiquinone”, “Energy Metabolism”, “Biochemistry”, “Drug Target” and “Drug Development”, my current research area include Trypanosomatids and Apicomplexan parasites, Helminthes and Tumor Microenvironment.
Ph.D. (Veterinary Medicine), National License of veterinarian
Department of Virology, Institute of Tropical Medicine (I.T.M), Nagasaki University
Development of diagnostics for mosquito-borne viral diseases (dengue virus, Japanese encephalitis virus, Rift Valley fever virus, chikungunya virus, West Nile virus etc.)
Currently, I am working together with Kenyan students and young researchers for the development of diagnostics for mosquito borne viral diseases in Kenya. The highest priority criterion for me to choose research topics for my students and myself are based on the local needs in the tropics and it is also related to the development of diagnostics.
More than a 30-year experience and hands-on a broad variety of molecular laboratory techniques and instrumentations, experimental design and data analysis, laboratory management, instructorship and supervision.
Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University
1995/01–1996/11, Postdoctoral Research Associate, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA1994/06, PhD (biochemistry and immunology), Rostov State Medical Institute, Rostov-on-Don, Russia1981/09–1987/02, M.S. [equivalent] in chemical engineering of biologically active substances, Lomonosov Institute of Fine Chemical Technology, Moscow, Russia
Thyroid carcinogenesis, molecular carcinogenesis, radiation-induced carcinogenesis, molecular epidemiology, molecular diagnostics, radiation and cancer epidemiology, radiation biology, human genetics, molecular pathology. An author and coauthor of 117 peer reviewed articles, 2 books, 9 book chapters, 23 Professional societies’ publications, peer review service to 19 international journals, Member of Editorial board in 2 journals.
We are aimed at designing and conducting laboratory and epidemiological research into the contribution of inherited genetic variations and somatic genetic alterations to the etiology of human cancer and non-cancer diseases, particularly focusing on populations exposed to radiation in Chernobyl, Kazakhstan and Japan to improve public health through gaining new insights into gene-environmental interactions.
BSc, MAppStats, PhD
School of Tropical Medicine and Global Health, Nagasaki University, Japan
Chris received his Bachelor of Science from the University of Nebraska-Lincoln (USA) (2002), a Master of Applied Statistics with distinction from the University of Malaya (Malaysia) (2005), and a PhD in Health Science from the University of Tokyo (Japan) (2011) for research on statistical method to measure the relative performance of post-market treatments in the absence of suitable controls. Following completion of his PhD, he went on to hold a postdoctoral position at the National Institute for Environmental Studies (Japan) where he studied the health effects of ambient temperatures and air pollution in Japan. In 2013, he became a postdoctoral fellow under the Japan Society for the Promotion of Science and expanded his work on environmental pollution and health to the developing countries in the tropics. He continued his work as an assistant professor at the Institute of Tropical Medicine, Nagasaki University (Japan), from late 2015 until early 2018. From April 2018, he joined the School of Tropical Medicine and Global Health at the same university as an Associate Professor. He was a Rutherford Fellow at the London School of Hygiene and Tropical Medicine (United Kingdom) between August 2018 to January 2019.
Chris teaches biostatistics at the School of Tropical Medicine and Global Health at Nagasaki University, and previously, the School of International Health at the University of Tokyo. He has previously organized and taught undergraduate courses in statistics, actuarial mathematics, and quantitative analysis.
Chris is interested in environmental epidemiology and the related statistical methods. His research focuses on the assessment of human health risk associated with atmospheric exposures such as air pollution, ambient temperatures, airborne pollen, and intercontinental dust events. He is currently leading a project to measure the health impacts of landscape fires that affect the air quality of many Southeast Asian cities. He is involved in a project that investigates the associations of fine particulate matter, its chemical constituents and sources with the lung function of asthma patients. He is also leading a study to examine the forward displacement of daily mortality attributable to air temperatures in tropical setting.
Given his extensive training in applied statistics, Chris is also interested in the application of statistics in a multidisciplinary context involving other health fields and looks forward to working with researchers from different backgrounds.
In the digital age where data are collected faster and greater in quantity, strong quantitative skills are important to allow one to extract useful information from data. Statistics is central to this process. As you begin your journey with us, there will be opportunities to gain knowledge in statistical inference and develop skills in data analysis and interpretation. You will also be exposed to the data-driven approaches in epidemiology. I look forward to meeting students and researchers interested in utilizing these skills to improve health.
PhD in Social Anthropology
School of Global Humanities and Social Sciences, Nagasaki University
Socio-anthropological study on history, socio-cultural dynamics, inter-ethnic conflict, modernization and development among the Banna in southern Ethiopia since 1993. Study on medical anthropology and medical pluralism since 2008. Study on population aging and elderly care since 2012.
I am currently involved in research teams on global aging, especially focusing on future aging and social welfare in Africa. Both qualitative and quantitative research on elderly life, health, care and social protection will be carried out in East Africa; Ethiopia, Kenya, Uganda, and Zambia.
I have been carrying out anthropological fieldwork on tradition and the modernization process in an agro-pastoral society, the Banna, in Ethiopia, northeast Africa since 1993. Watching a small remote society connect with, and getting swallowed by globalization reveals both positive and negative aspects of “development”. I explore the ideal relationship between traditional culture and society, modernization and development through the anthropological approach to international healthcare.
MD, MSc, PhD
I have been working in the field of maternal health. Pregnancy and childbirth are mostly physiological processes. In some cases, however, there are pathological aspects as well. Both physiology and pathology must be taken into account when considering maternal health. Unfortunately, only pathological phenomenon is focused on, as exemplified in the saying that “Every pregnancy is a risk”. Therefore, there is a huge misuse of medical interventions observed, both in developing and industrialized countries. We should strive to find an optimal point in between the two, keeping in mind that that point is variable. There is no “magic bullet” in the field of public health. We must think together how we can change this world.
I am in charge of the two following modules
Cambodia (capital – Phnom Penh, rural – Prey Veng province)
My research field is ‘maternal health’ and ‘quality of health care’. These topics
contribute to make the pregnancy and delivery process safer and to provide quality care to mothers, babies and family members.
Pregnancy and delivery are basically a physiological process, however, complications may occur, so maternal health should deal with both physiological and pathological issues. The means is not limited to medical technology. We should consider those who are giving birth for our future, therefore, our values and commitment towards self, others and society are always tested.
B.Sc., M.Sc., Ph.D.
2015-present Associate Professor, Institute of Tropical Medicine, Nagasaki University
2015-present Deputy Director, WHO Collaboration Center for Research and Reference of Tropical Viral Diseases
2015-present Research Collaborator, National Institute of Infectious Diseases
2010-2014 National Institute of Infectious Diseases, Researcher
2006-2010 National Institute of Infectious Diseases, Ph.D. attachment program
2006-2010 Tsukuba University (Ph.D. in Medical Sciences)
2004-2006 Tsukuba University (M.Sc. in Medical Sciences)
2003-2004 Tsukuba University (Japanese language and Culture studies)
1999-2002 Universiti Putra Malaysia (B.Sc. in Microbiology, First Class Honours)
Lectures on Virology and infection immunity, Ph.D. and M.Sc. graduate research
I have been working on researches on prevention measures of arthropod-borne viral diseases, particularly on dengue. My primary research goals are directed toward understanding the basis of the development of an effective vaccine for prevention measures against dengue fever. My previous projects have led to the successful development of in vitro and in vivo models for the dengue vaccine evaluation studies. The novel models have also lead to a better understanding of the immune responses induced after dengue vaccination and infection. Using these novel tools, my future plans are aimed at developing an effective and safe dengue vaccine, to contribute to the reduction of dengue disease burden worldwide.
Research activities of our group, Department of Virology, Institute of Tropical Medicine are as follows:
Field epidemiology on arthropod borne diseases in Vietnam, Myanmar, Philippines, Kenya, Nepal, Malaysia, Sri Lanka.
Vaccine and therapeutic development against dengue and other arthropod-borne diseases
Identification of factor(s) involved in the pathogenesis of dengue and other arthropod-borne diseases
Development of rapid diagnostics for dengue and other arthropod-borne diseases
With rapid globalization and changes in the population dynamics, health problems in tropical regions is changing and diversifying profoundly. Innovative measures are therefore needed to enable solutions to meet rapidly evolving needs and to provide new perspectives to develop effective control measures. In the recent decades, we have seen a surge of global infectious disease epidemics- there is an increasing need for cross-sector and collaborative efforts between different fields to rapidly address challenges and introducing effective control measures. Basic research addressing pathogenicity remains key in developing effective measures, including therapeutics and vaccines. For this reason, our research aims to bring together basic virology reach, from bench to the field, in collaboration with multinational researchers from diverse disciplinary, to explore on innovative solutions against dengue and other arthropod borne diseases.
Here, we would like to engage with students on educational and research activities in the development of effective strategies against major infectious diseases of global public health threat.
PhD in malaria parasite genetics
Malaria Unit, Institute of Tropical Medicine, Nagasaki University
My lab focuses on genetic and genomic approaches to identify the underlying genetic causes of medically important phenotypic differences between parasite strains. We use the rodent malaria parasites for some of these studies, but we are increasingly pursuing investigations involving the human malaria parasites in in vitro culture, and non-human primate malaria parasites such as Plasmodium cynomolgi in monkeys. We also work in malaria endemic countries on epidemiology related projects, including with P. falciparum and P. vivax in Africa, P. knowlesi and P. cynomolgi in Southeast Asia, and P. simium and P. brasilianum in South America. We are interested in ALL aspects of malariology.
For an up to date publication list, please see:
The Malaria Unit at the Institute of Tropical Medicine is a dynamic and cosmopolitan laboratory specializing in the genetics and epidemiology of malaria. Although we take our scientific research very seriously, we endeavour to create a fun and relaxing environment for lab members, as we believe that science should be enjoyable and rewarding for the researcher.
We work on multiple disciplines within malariology, and try to accommodate each individual lab member’s research interests. We rely on a large network of international collaborators for the vast majority of our research projects, and currently have active partnerships with researchers in numerous regions including the UK, Portugal, Saudi Arabia, Brazil, Nigeria, Kenya, Thailand and elsewhere.
All research and lab life is conducted in English (with a smattering of Swahili, Welsh and American).
Our lab offers graduate students a relaxed and informal atmosphere in which to explore their own research interests with strong academic support and guidance if required.
Potential projects available with our lab include (but are not limited to); studies of inter-species interactions between malaria parasite strains and species within mice and mosquitoes; discovery of genes involved in drug resistance/ virulence/ strain-specific immunity in rodent malaria parasites through genetic crossing and whole genome sequencing; studies involving investigation of the conditions required for optimal vectorial capacity in mosquitoes; studies on the population genetics of P. falciparum, P. malariae and P. ovale in field isolates from Nigeria.
We also strongly encourage potential graduate students to design their own research utilizing the resources of the Malaria Unit. These include the largest collection of rodent malaria parasite isolates in the world, a colony of A. stephensi mosquitoes in a state-of-the-art insectary for transmission experiments, and access to field isolates from our international collaborators.
Ph. D. (Medicine)
Department of International Medicine, Institute of Tropical Medicine, Nagasaki University
Molecular Epidemiology: genomics, bioinformatics, geography
Zoonosis and host adaptation: diseases ecology, molecular evolution, One Health, conservation medicine
Not only tropical medicine, theoretical and basic sciences should be considered as an essential standpoint. It is recommended that Ph. D. candidates in our group keep an affinity to both applied and basic (logical) sciences flexibly, to confront own research purposes step by step.