Assistant professor Tomohiro Koga

Speciality / Research theme / Keywords
Collagen Diseases, Allergology, Immunology
Masters ProgrammeDoctoral Programme


  • Doctor of Medicine (Nagasaki University)
  •  Medical license

Personal/work Web page addresses


Research gate account links



  • Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • Nagasaki university hospital, Medical education development center


  • April 2005 – March 2009 National Organization Hospital Organization Nagasaki Medical Center
  • April 2009 – May 2011 Nagasaki University Hospital Department of rheumatology
  • June 2011 – February 2014 Harvard Medical University (Beth Israel Deaconess Medical Center, Rheumatology Division, Dr. Tsokos Lab), research fellow
  • March 2014 – November 2016 Nagasaki University Hospital Medical Education Development Center, assistant professor
  • December 2016 – present Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, assistant professor (the Leading Initiative for Excellent Young Researchers of the Ministry of Education, Culture, Sports, Science and Technology)


Diagnostics: practical training on collagen diseasesEducation for medical intern


  • Studies on T cell signaling in autoimmune diseases
  • Research on gene analysis and cytokine analysis in autoinflammatory diseases

The country/countries where you work currently


Five MOST IMPORTANT/INTERESTING recent publications

  1. Umeda M, Koga T (corresponding author), Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri SY, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y, Kawakami A. CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus. Clin Immunol. 2017 Oct 13. pii: S1521-6616(17)30567-3.
  2. Koga T, Kawashiri SY, Migita K, Sato S, Umeda M, Fukui S, Nishino A, Nonaka F, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Eguchi K, Kawakami A. Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients. Scand J Rheumatol. 2017 Sep 2:1-3. doi: 10.1080/03009742.2017.1363281.
  3. Koga T, Otomo K, Mizui M, Yoshida N, Umeda M, Ichinose K, Kawakami A, Tsokos GC. Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases. Arthritis Rheumatol. 2016 Aug;68(8):1981-8. doi: 10.1002/art.39665.
  4. Otomo K, Koga T (co-first author), Mizui M, Yoshida N, Kriegel C, Bickerton S, Fahmy TM, Tsokos GC. Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice. J Immunol. 2015 Dec 15;195(12):5533-7. doi: 10.4049/jimmunol.1501603.
  5. Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC. CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.


As a clinician with researchers’ eyes, we are conducting research that can contribute to practical use for patients based on clinical questions as a rheumatologist. In order to solve the unmet medical needs of autoimmune diseases and autoinflammatory diseases which are regarded as rare intractable diseases, we are looking for fellows who can study together.