Faculty

Professor Koji Maemura

Speciality / Research theme / Keywords
Cardiovascular Medicine
Supervision
Masters Programme

Qualifications

MD, PhD

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/junkanki/index.html

Affiliation(s)

  • Department of Cardiovascular Medicine, Nagasaki University graduate School of Biomedical Sciences
  • Department of Cardiovascular Medicine, Nagasaki University Hospital

Background

  • 1986-88 Resident, Internal Medicine, Tokyo University Hospital
  • 1988-90 Clinical Fellow, Cardiology, Mitsui Memorial Hospital
  • 1990-96 Clinical & Research Fellow, The 3rd Department of Internal Medicine, University of Tokyo
  • 1996 Instructor, The 3rd Department of Internal Medicine, University of Tokyo
  • 1996-2000 Research Fellow, Center for the Prevention of Cardiovascular Disease, Harvard School of Public Health
  • 2000 Research Fellow, Division of Cardiology, Brigham & Women’s Hospital, Harvard Medical School
  • 2001-2008 Assistant Professor, Department of Cardiovascular Medicine, University of Tokyo
  • 2008- Professor, Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

Teaching

Cardiovascular Disease has been a major cause of death in developed countries. Also in developing countries, obesity, diabetes, and hypertension are increasing due to the change of lifestyle, resulting in the rapid increase of cardiovascular disease. Although infectious diseases has been the most important conventional health problem in developing countries, it will become very important to prevent and treat lifestyle-related diseases in the near future. I would like to learn how to prevent and treat cardiovascular disease, and how to educate people together with you.

Research

  • Previous studies reported that night shift workers had a high risk of ischemic heart disease, suggesting a close association between cardiovascular diseases and circadian rhythm. In addition, recent studies obtained from the genetically engineered mice with disrupted circadian rhythm have revealed that the circadian clock is closely related to the pathogenesis of cardiovascular diseases and metabolic disorders. We are investigating the biological relevance of the biological clock in the development of cardiovascular diseases and trying to develop chronotherapeutic approaches to the prevention and treatment of cardiovascular diseases.
  • Recent studies have revealed that acute myocardial infarction (AMI) mostly arises as a result of thrombotic coronary occlusion after the rupture of a vulnerable plaque. Thus, identifying vulnerable plaque before AMI is important to prevent AMI. We are searching blood biomarkers to easily detect the presence of vulnerable plaque.

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Koga S, Honda S, Maemura K, Nishihira K, Kojima S, Takegami M, Asaumi Y, Yamashita J, Saji M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S and Investigators J. Effect of Infarction-Related Artery Location on Clinical Outcome of Patients With Acute Myocardial Infarction in the Contemporary Era of Percutaneous Coronary Intervention- Subanalysis From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). Circ J. 2022;86:651-659.
  2. Koga S, Honda S, Maemura K, Nishihira K, Kojima S, Takegami M, Asaumi Y, Yamashita J, Saji M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S and Investigators J. Effect of Infarction-Related Artery Location on Clinical Outcome of Patients With Acute Myocardial Infarction in the Contemporary Era of Percutaneous Coronary Intervention- Subanalysis From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). Circ J. 2022;86:651-659.
  3. Koga S, Ikeda S, Akashi R, Yonekura T, Kawano H and Maemura K. Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease. J Cardiol. 2021;77:583-589.
  4. Nakata T, Ikeda S, Koga S, Yonekura T, Tsuneto A, Doi Y, Fukae S, Minami T, Kawano H and Maemura K. Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia. Int Heart J. 2020;61:984-992.
  5. Wei S, Isagawa T, Eguchi M, Sato D, Tsukano H, Miyata K, Oike Y, Takeda N, Ikeda S, Kawano H and Maemura K. Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia. Biomedicines. 2020;8.470

Message

Cardiovascular Disease has been the major cause of death in developed countries, however the death rate has been decreasing due to preventive medicine and the development of new therapies. On the other hand, in developing countries, obesity, diabetes, and hypertension are increasing due to the change in lifestyle, resulting in a rapid increase in cardiovascular disease. Although infectious diseases have been the most important health problems conventionally in developing countries, it will become very important to prevent and treat lifestyle-related diseases in the near future. I would like to learn how to prevent and treat cardiovascular disease, and how to educate people together with you.

 

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