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松井 三明 准教授

    修了課程: 修了年度:

取得学位・資格

MD, MSc, PhD

ResearchGate/LinkedInアカウント

mmatsui@nagasaki-u.ac.jp

経歴

I have been working in the field of maternal health. Pregnancy and childbirth are mostly physiological processes. In some cases, however, there are pathological aspects as well. Both physiology and pathology must be taken into account when considering maternal health. Unfortunately, only pathological phenomenon is focused on, as exemplified in the saying that “Every pregnancy is a risk”. Therefore, there is a huge misuse of medical interventions observed, both in developing and industrialized countries. We should strive to find an optimal point in between the two, keeping in mind that that point is variable. There is no “magic bullet” in the field of public health. We must think together how we can change this world.

教育活動

I am in charge of the two following modules

  • “Reproductive Health and Gender”Objective: to obtain necessary knowledge in order to control maternal morbidity and mortality and gender issues in developing countries.
  • “Program and Project Management”Objective: to obtain necessary knowledge and skill to manage public health program/projects in developing countries.

研究活動

  • “The impact of the improvement of the quality of care in maternity on maternal and neonatal health in health centers in Cambodia.”Outline – Evidence-based maternity and neonatal care is not well provided at health facilities in many developing countries, therefore the quality of care is substandard. However, international societies put immense pressure on the promotion of facility-based delivery regardless of the quality of care. We carry out an evaluation of maternal and neonatal conditions during labor and the postpartum period and observe the changes after an intervention, which aims to improve the quality of care during maternity.
  • “Factors of chronic malnutrition among children under 2 years old in rural Cambodia.”Outline – Approximately one out of four children aged 24 months demonstrated being “underweight” (weight for age < -2 s.d.) in rural Cambodia. This rate progressively increased with the age of the children. This study employs a prospective design to observe the changes of weight related to age and its associated factors in rural Cambodia.

現在の主な研究活動地域

Cambodia (capital – Phnom Penh, rural – Prey Veng province)

最近の5つの出版物

  1. Suto M, Takehara K, Misago C, Matsui M. Prevalence of perineal lacerations in women giving birth at midwife-led birth centers in Japan: A retrospective descriptive study. J midwife women health. in press(2015)
  2. Noguchi M, Matsui M, Osanai Y, Horikoshi Y, Takehara K, Misago C. Women-friendly childbirth experience Cambodia. J Int Health 29(4): 81.(2014)
  3. Matsui M, Sokhan U, Keth LS, Tung R.Equity gap in utilisation of emergency obstetric care service in Cambodia, from 2007 to 2009. Trop Med Int Health. 18(suppl 1): 187.(2013)
  4. Iwamoto A, Matsui M, Okabayashi H. Review of maternal, neonatal and child health integrated services in the southern four provinces in Lao PDR. Trop Med Int Health. 18(suppl 1): 186.(2013)
  5. Honda A, Randaoharison PG, Matsui M. Affordability of emergency obstetric and neonatal care at public hospitals in Madagascar. Reprod Health Matters. 19: 10-20.(2011)

メッセージ

開発途上国での妊娠,出産を安全にすること,また産む女性,生まれてくる子ども,そして家族にとってより良いものにしていくことを研究課題としています。
妊娠と出産は生理学的な事象ですが,時に合併症を伴います。よって正常から異常までの広い範囲に対応することが必要です。これらの対応とは,単に医学的なものだけではなく,次世代へ生をつなげようとする人々への、さらには社会に対しての関わりであり,そこに携わるひとりひとりの姿勢,ありようが問われるものです。
公衆衛生に関わるということは,すなわちクリアカットには割り切れない「社会的存在」としての人間の課題に取り組むことであり,この点に学問のおもしろさがあるのです。

古賀 智裕 助教

    修了課程: 修了年度:

取得学位・資格

  • 医学博士(長崎大学)
  • 医師免許

個人/所属ウェブページ

http://www.med.nagasaki-u.ac.jp/intmed-1/

ResearchGateアカウント

https://www.researchgate.net/profile/Tomohiro_Koga

他所属

  • 長崎大学病院第一内科(リウマチ・膠原病内科)
  • 長崎大学病院医療教育開発センター

経歴

  • 2005年4月~2009年3月 独立行政法人国立病院機構 長崎医療センター
  • 2009年4月~2011年5月 長崎大学病院 第一内科 リウマチ・膠原病内科 医員
  • 2011年6月~2014年2月 ハーバード医科大学(Beth Israel Deaconess Medical Center, Rheumatology Division, Dr.Tsokos Lab)
  • 2014年3月~2016年11月 長崎大学病院 医療教育開発センター 助教2016年12月〜現在 長崎大学大学院医歯薬学総合研究科 分子標的医学研究センター 助教(平成28年度科学技術人材育成費補助事業「卓越研究員事業」卓越研究員)

教育活動

  • 診断学:膠原病 各論実習
  • 研修医教育
  • 指導医講習会世話人

研究活動

  • 自己免疫疾患におけるT細胞シグナル伝達に関する研究
  • 自己炎症性疾患における遺伝子解析、サイトカイン解析に関する研究

現在の主な研究活動地域

日本

最近の5つの出版物

  1. Umeda M, Koga T (corresponding author), Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri SY, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y, Kawakami A. CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus. Clin Immunol. 2017 Oct 13. pii: S1521-6616(17)30567-3.
  2. Koga T, Kawashiri SY, Migita K, Sato S, Umeda M, Fukui S, Nishino A, Nonaka F, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Eguchi K, Kawakami A. Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients. Scand J Rheumatol. 2017 Sep 2:1-3. doi: 10.1080/03009742.2017.1363281.
  3. Koga T, Otomo K, Mizui M, Yoshida N, Umeda M, Ichinose K, Kawakami A, Tsokos GC. Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases. Arthritis Rheumatol. 2016 Aug;68(8):1981-8. doi: 10.1002/art.39665.
  4. Otomo K, Koga T (co-first author), Mizui M, Yoshida N, Kriegel C, Bickerton S, Fahmy TM, Tsokos GC. Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice. J Immunol. 2015 Dec 15;195(12):5533-7. doi: 10.4049/jimmunol.1501603.
  5. Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC. CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.

メッセージ

研究者の目を持つ臨床医としてリウマチ膠原病内科医としてクリニカルクエスチョンを基に、最終的には患者さんに還元し実用化可能な研究を行っています。希少難病とされる自己免疫疾患や自己炎症性疾患のアンメット・メディカル・ニーズを解決するため、ともに研究できる仲間を募集しています。

砂原 俊彦 助教

    修了課程: 修了年度:

取得学位・資格

博士(医学)

経歴

1994 – 2003:佐賀大学
2004 – 現在: 長崎大学

教育活動

TMGH 修士課程、熱帯医学研修課程

研究活動

デング熱媒介蚊の生態と防除等

現在の主な研究活動地域

  • 日本

最近の5つの出版物

  1. Sunahara T. 2019. Effects of filling catch basins with Mosquito Eliminating Mat on mosquito populations. Medical Entomology and Zoology (in press) [Japanese]
  2. Sunahara T. 2019. Extremely high biting densities of Aedes albopictus (Skuse)(Diptera: Culicidae) at a university campus in Nagasaki, Japan. Japanese Journal of Infectious Diseases (in press)
  3. Imanishi N, Higa Y, Teng HJ, Sunahara T, Minakawa N. 2018. Identification of Three Distinct Groups of  in Japan by Morphological and Genetic Analyses. Japanese Journal of Infectious Diseases 71(6): 427-435.
  4. Sunahara T 2018. Simulation Study of the Effects of Host Availability on Bite Rate of Aedes albopictus (Skuse) (Diptera: Culicidae) and Risk of Dengue Outbreaks in Non-Endemic Areas. Japanese Journal of Infectious Diseases 71(1): 28-32.
  5. Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S. 2017. Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya. PLoS Neglected Tropical Disieses 11(9): e0005872

メッセージ

自分の興味に関係する過去の論文を読んで学問的な背景を把握して、重要なのにまだ明らかになっていないことを明確にしてそれをResearch Questionとして具体的な研究方法を考えられれば、研究の70%は完成していると思います。実際に実験や調査を始める前の準備段階を大切にしましょう。

Bhim Gopal Dhoubhadel 助教

    修了課程: 修了年度:

取得学位・資格

MBBS, MTM, PhD

ResearchGate/LinkedInアカウント

Twitterアカウント

https://twitter.com/bhim_gopal

経歴

I received my medical degree from BP Koirala Institute of Health Sciences (BPKIHS), Nepal in 2005 and then worked for three years in paediatric hospitals in Nepal followed by one year in a refugee camp for Somali and Ethiopian refugees under UNHCR in Djibouti. Between 2010-11, I completed the Master of Tropical Medicine (MTM) programme in the Institute of Tropical Medicine, Nagasaki University and then a PhD in the Department of Clinical Medicine of the same institute between 2011 and 2014. In 2014, I was a Fellow of the Global (Health) Leadership Program at the University of Tokyo and completed an internship at the headquarters of the World Health Organization (WHO) in Geneva. My research interests are infectious diseases, child health and development of new diagnostic assays. In 2014, we established a new diagnostic assay for serotyping the pneumococcus (a major cause of pneumonia). The assay can identify vaccine serotypes easily and conveniently at a relatively low cost and has been applied in studies in Japan, Vietnam and Afghanistan.

教育活動

At TMGH, I teach master students about essential skills and tropical medicine (clinical bacteriology and molecular diagnostic technique), and organize and facilitate clinical case discussion between the students and doctors in San Lazaro Hospital (Philippians), Bach Mai Hospital (Vietnam) and National Center for Global Health and Medicine (Japan).

Previously I taught advanced paediatric life support (APLS) course to junior medical doctors in Siddhartha Children and Women Hospital, Nepal and child health and management of malnutrition to medical and nursing staffs in Djibouti.

研究活動

I have studied the distribution of pneumococcal serotypes in hospital admitted children and adults in Japan, Vietnam and Afghanistan with a particular focus on the estimation of pneumococcal vaccine coverage.

After I participated in relief efforts following the earthquake in 2015 in Nepal, we are developing a research collaboration with Siddhi Memorial Hospital, Bhaktapur (http://smf.org.np). The focus is on childhood infectious diseases and malnutrition. We are supporting hospital disease surveillance and have conducted nutritional assessments of children who were displaced by the earthquake and living under temporary shelters.

At TMGH, we are establishing new diagnostic assays for typhoid fever based on real-time PCR and loop-mediated isothermal amplification (LAMP). We plan to evaluate these assays in Nepal and other field sites.

bhim_1
Picture1:Disease surveillance in Siddhi Memorial Hospital, Bhaktapur, Nepal.


bhim_2
Picture 2: Nutritional assessment of children in temporary shelters in Bhaktapur after 2015 earthquake in Nepal.


現在の主な研究活動地域

  • Japan
  • Nepal
  • Afghanistan

最近の5つの出版物

  1. Kakiuchi S, Suzuki M, Dhoubhadel BG, Furumoto A, Ito H, Kei Matsuki, Tsuchihashi Y, Asoh N, Yasunami M, Ariyoshi K, Morimoto K, Adult Pneumonia Study Group-Japan (2018). Accuracy of high-throughput nanofluidic PCR-based pneumococcal serotyping and quantification assays using sputum samples for diagnosing vaccine serotype pneumococcal pneumonia: analyses by composite diagnostic standards and Bayesian latent class models, J Clin Microbiol.
  2. Shrestha D, Dhoubhadel BG, Parry CM, Prajapati B, Ariyoshi K, Mahaseth C (2017). Predicting deaths in a resource-limited neonatal intensive care unit in Nepal, Trans R Soc Trop Med Hyg.
  3. Zabihullah R, Dhoubhadel BG, Rauf RA, Shafiq SA, Suzuki M, Watanabe K, Yoshida LM, Yasunami M, Zabihullah S, Parry CM, Mirwais R, Ariyoshi K (2017). Risk for death among children with pneumonia, Afghanistan, Emerg Infect Dis.
  4. Suzuki M, Dhoubhadel BG, Ishifuji T, Yasunami M, Yaegashi M, Asoh N, Ishida M, Hamaguchi S, Aoshima M, Ariyoshi K, Morimoto K; Adult Pneumonia Study Group-Japan (APSG-J) (2016). Serotype-specific effectiveness of the 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia among adults aged ≥65 years: a multicenter prospective test-negative design study, Lancet Infect Dis.
  5. Dhoubhadel BG, Yasunami M, Nguyen HA, Suzuki M, Vu TH, Thi Thuy Nguyen A, Dang DA, Yoshida LM, Ariyoshi K (2014) Bacterial Load of Pneumococcal Serotypes Correlates with Their Prevalence and Multiple Serotypes is Associated with Acute Respiratory Infections, PLoS One.

すべての出版物へのリンク

http://www.ncbi.nlm.nih.gov/sites/myncbi/1pMFjL8tdMn55/bibliography/40287257/public/?sort=date&direction=ascending

メッセージ

Clinical infectious diseases, child health and vaccination are some of the inter-related exciting fields of global health.
We have been working in these areas and found that there are lots to discover, learn and contribute on these topics globally.
We hope you will find them interesting and contribute while you study here at TMGH. Welcome!

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