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稲岡 健 ダニエル 准教授

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薬学博士

ResearchGateアカウント

https://www.researchgate.net/profile/Daniel_Inaoka

他所属

東京大学医学系研究科・生物医化学教室・客員研究員

経歴

稲岡 健ダニエル博士(薬学)は2000年にブラジル東北部に位置するUniversidade Federal do Rio Grande do Norteで薬学部を卒業し、2000年から2005年の期間で東京大学薬学系研究科の修士及び博士課程を修了した。その後、東京大学医学系研究科で2007年までJSPS外国人特別研究員、2007年から2016年まで同研究科で助教として在籍した。長崎大学TMGHには2016年から助教(卓越)として赴任している。

教育活動

2002年から2005年まで、帝京大学医学部・物理学の非常勤講師として実習を担当。また、2007年から2016年まで東京大学医学系研究科・国際保健学専攻で生化学実習を担当した。長崎大学・TMGHではBasic Human Biologyの講義を北先生・神谷先生と共に講義を行う。

研究活動

稲岡は大学院でシャーガス病を引き起こすTrypanosoma cruziのピリミジン・エネルギー代謝経路の研究を行い、生化学・生物物理学・分子生物学・構造生物学・ケミカルバイオロジーといった手法を駆使して基礎研究及び創薬研究を行ってきた。外国人特別研究員・助教となってからは、分野を広げアフリカ睡眠病を引き起こすT. bruceiやリーシュマニア症を引き起こすLeishmania spp、熱帯熱マラリアを引き起こすPlasmodium falciparum等の寄生原虫の他、ブタ回虫(Ascaris suum)、アニサキス(Anisakis spp)、捻転胃虫(Haemonchus contortus)、肝蛭(Fasciola spp)、等の蠕虫で行われる微好気的エネルギー代謝の研究とそれによって支えられている寄生現象の分子機構を明らかにするための研究を行っている。その他にSATREPSプログラム「インドネシアの生物資源多様性を利用した抗マラリア・抗アメーバ新規薬剤リード化合物の探索」の研究分担者として、インドネシアで研究・実験の指導を行っている。対象疾患は幅広く、「寄生虫」、「ミトコンドリア」、「宿主環境適応」、「ユビキノン」、「エネルギー代謝」、「生化学」、「薬剤標的」、「薬剤開発」といったキーワードを基盤とした研究活動を行っている。

現在の主な研究活動地域

  • 日本
  • インドネシア
  • エル・サルバドル

最近の5つの出版物

  1. Hartuti ED, Inaoka DK (Corresponding Author, CA), Komatsuya K, Miyazaki Y, Miller RJ, Xinying W, Sadikin M, Prabandari EE, Waluyo D, Kuroda M, Amalia E, Matsuo Y, Nugroho NB, Saimoto H, Pramisandi A, Watanabe YI, Mori M, Shiomi K, Balogun EO, Shiba T, Harada S, Nozaki T, Kita K. Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Biochim Biophys Acta. 2018 Mar;1859(3):191-200.
  2. Wang X, Inaoka DK (CA), Shiba T, Balogun EO, Allmann S, Watanabe YI, Boshart M, Kita K, Harada S. Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Protein Expr Purif. 2017 Oct;138:56-62.
  3. Inaoka DK, Iida M, Hashimoto S, Tabuchi T, Kuranaga T, Balogun EO, Honma T, Tanaka A, Harada S, Nara T, Kita K, Inoue M. Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. Bioorg Med Chem. 2017 Feb 15;25(4):1465-1470.
  4. Inaoka DK (CA), Iida M, Tabuchi T, Honma T, Lee N, Hashimoto S, Matsuoka S, Kuranaga T, Sato K, Shiba T, Sakamoto K, Balogun EO, Suzuki S, Nara T, Rocha JR, Montanari CA, Tanaka A, Inoue M, Kita K, Harada S. The Open Form Inducer Approach for Structure-Based Drug Design. PLoS One. 2016 Nov 28;11(11):e0167078.
  5. Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S. Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria. Int J Mol Sci. 2015 Jul 7;16(7):15287-308.

井上 真吾 准教授

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獣医学博士、獣医師

個人/所属ウェブページ

http://www.tm.nagasaki-u.ac.jp/nekken/research/virology.html

他所属

熱帯医学研究所ウイルス学分野

経歴

  • 平成29年2月より熱研ウイルス学分野准教授として勤務(現在に至る)
  • 平成21年10月よりJICA専門家として約8年間ケニア中央医学研究所にてアルボウイルスの研究、国際協力事業(個別派遣、SATREPS等)を行う。
  • 平成13年12月より熱研ウイルス学分野助手(助教)として勤務
  • 平成11年4月から平成13年11月までフィリピン、セント・ルークスメディカルセンターにてポスドクとして研究(約3年間)
  • 平成9年4月から平成11年3月までポスドクとして熱研ウイルス学分野にて研究
  • 平成9年3月:岐阜大学大学院 連合獣医学研究科 獣医学専攻 博士課程修了
  • 平成3年7月まで:青年海外協力隊(獣医師隊員)としてザンビア共和国ザンビア大学獣医学部に勤務(3年間)
  • 昭和63年3月:北里大学大学院 獣医学研究科 獣医学専攻 修士課程修了

教育活動

  1. 熱帯医学研修課程および熱帯医学修士課程にてウイルス学実習を担当。
  2. ケニアにて博士課程3名(内2名は修了して学位取得)、修士課程4名(内2名は修了して学位取得)を指導。
  3. 日本にて博士課程進学予定のケニア人研究生2名とコンゴ民主共和国人1名の合計3名に対してウイルス学および分子生物学の基礎実験を指導中。

研究活動

蚊が媒介するウイルス(アルボウイルス)の迅速診断法の開発を主に行っている。(黄熱、デング熱、リフトバレー熱、チクングニア熱、日本脳炎、西ナイル熱など)

現在の主な研究活動地域

「ケニアにおける黄熱病およびリフトバレー熱に対する迅速診断法の開発とそのアウトブレイク警戒システムの構築プロジェクト」

本プロジェクトは、平成24年1月から平成29年1月までの5年間、地球規模課題対応国際科学技術協力(SATREPS)事業として実施された。ケニア中央医学研究所(Kenya Medical Research Institute:KEMRI)での黄熱病、リフトバレー熱の迅速診断法の実用化、リファレンス機能強化、更に、地域の医療施設、KEMRI、ケニア公衆衛生省を結ぶ携帯電話網を活用したアウトブレイク早期警戒・即時対応メカニズムの構築を目指している。本プロジェクト終了後の現在は、そのフォローアップ支援活動および共同学術研究を継続して行っている。

最近の5つの出版物

  1. Adungo F, Yu F, Kamau D, Inoue S, Hayasaka D, Posadas HG, Sang R, Mwau M, Morita K, Development and Characterization of monoclonal antibodies to yellow fever virus and their application in antigen detection and IgM capture ELISA. Clinical and Vaccine Immunology, on line 15 June 2016.1-38 (2016)
  2. Yoshikawa A, Nabeshima A, Inoue S, Agoh M, Morita K, Molecular and serological epidemiology of Japanese encephalitis virus (JEV) in a remote island of western Japan: an implication of JEV migration over the East China Sea., Tropical Medicine and Health, 44(8): 1-10 (2016)
  3. Inoue, S, Bundi M, Miring’u G, Muriithi B, Ashur S, Wandera E, Kathiiko C, Odoyo E, Kwallah AO, Galata A, Huka S, Shah M, Karama M, Kariuki S, Ichinose Y, Evaluation of a BSL-3 laboratory biosafety training program in Kenya. Journal of Biotechnology and Biosafety, 3(4): 288-296, (2015)
  4. Wasonga C, Inoue S, Rumberia, C,  Michuki, G, Kimotho JH, Ongus J, Sang R, Musila L, Genetic divergence of chikungunya virus plaque variants from the Comoros Island (2005). Virus Genes, 51(3): 323-328 (2015)
  5. Kwallah AO, Inoue S, Thairu-Mwangi AW, Kuttoh N, Morita K, Mwau M. Seroprevalence of Yellow Fever virus in selected health facilities in Western Kenya 2010–2012. Jpn J Infect Dis, 68: 230-234, (2015)

メッセージ

これまで主に蚊媒介性のウイルス(アルボウイルス)について留学生および派遣国での現地大学院生と共に研究活動を行ってきました。熱帯地域の現地のニーズに根差した研究および診断キットの開発を行うことを研究テーマ選びの最重要項目としています。

Vladimir Saenko 准教授

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More than a 30-year experience and hands-on a broad variety of molecular laboratory techniques and instrumentations, experimental design and data analysis, laboratory management, instructorship and supervision.

個人/所属ウェブページ

http://www-sdc.med.nagasaki-u.ac.jp/dhrc/index-e.html

ResearchGateアカウント

https://www.researchgate.net/profile/Vladimir_Saenko

他所属

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University

経歴

学歴
1995/011996/11, Postdoctoral Research Associate, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA1994/06, PhD (biochemistry and immunology), Rostov State Medical Institute, Rostov-on-Don, Russia1981/091987/02, M.S. [equivalent] in chemical engineering of biologically active substances, Lomonosov Institute of Fine Chemical Technology, Moscow, Russia

職歴

  • 2012/06present, Associate Professor, Department of Radiation Molecular Epidemiology
  • Atomic Bomb Disease Institute, Nagasaki University

  • 2011/042012/06, Assistant professor, Department of Health Risk Control, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
  • 2002/042011/03, Assistant professor, Department of International Health and Radiation Research, Nagasaki University School of Medicine
  • 2000/05–2002/03, Visiting Professor, Department of International Health and Radiation Research, Nagasaki University School of Medicine
  • 1997/052000/04, Senior Scientist Molecular Biology division (Head), Department of Pathology, Medical Radiological research Center of RAMS, Obninsk, Russia
  • 1991/06–1997/04, Scientist, Department of Radiation Biochemistry, Medical Radiological research Center of RAMS, Obninsk, Russia
  • 1987/031991/05, Junior Scientist, Department of Radiation Biochemistry, Medical Radiological Research Center of RAMS, Obninsk, Russia

教育活動

  • 2013 – present, “Radiation and thyroid cancer” (medical student course), Fukushima Medical University
  • 2006 – 2014, “Molecular Biology, Gene expression, Genomics and Biotechnology” (foreign student course), Nagasaki University
  • 2003 – 2012, “Basics of Molecular Biology” (medical student course) Nagasaki University

研究活動

Thyroid carcinogenesis, molecular carcinogenesis, radiation-induced carcinogenesis, molecular epidemiology, molecular diagnostics, radiation and cancer epidemiology, radiation biology, human genetics, molecular pathology. An author and coauthor of 117 peer reviewed articles, 2 books, 9 book chapters, 23 Professional societies’ publications, peer review service to 19 international journals, Member of Editorial board in 2 journals.

現在の主な研究活動地域

日本

最近の5つの出版物

  1. Yamashita S, Suzuki S, Suzuki S, Shimura H, Saenko V. Lessons from Fukushima: Latest Findings of Thyroid Cancer after the Fukushima Nuclear Power Plant Accident. Thyroid 2017 Dec 1. doi: 10.1089/thy.2017.0283. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28954584
  2. Bogdanova TI, Saenko V, Hirokawa M, Ito M, Zurnadzhy LY, Hayashi T, Rogounovitch TI, Miyauchi A, Tronko MD, Yamashita S. Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine. Endocr J 2017, 64(10):977-993. doi: 10.1507/endocrj.EJ17-0134. https://www.jstage.jst.go.jp/article/endocrj/64/10/64_EJ17-0134/_pdf/-char/en
  3. Matsuse M, Yabuta T, Saenko V, Hirokawa M, Nishihara E, Suzuki K, Yamashita S, Miyauchi A, Mitsutake N. TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors. Scientific Rep 2017, 7:41752 doi: 10.1038/srep41752. PMID: 28150740. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288691/
  4. Nikitski A, Rogounovitch T, Bychkov A, Takahashi M, Yoshiura K, Mitsutake N, Kawaguchi T, Matsuse M, Drozd V, Demidchik Yu, Nishihara E, Hirokawa M, Miyauchi A, Rubanovich A, Matsuda F, Yamashita S, Saenko V. Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma. Thyroid 2017, 27(2):224-235. doi: 10.1089/thy.2015.0541. http://online.liebertpub.com/doi/pdf/10.1089/thy.2015.0541
  5. Takamura N, Orita M, Saenko V, Yamashita S, Nagataki S, Demidchik Yu. Radiation and risk of thyroid cancer: Fukushima and Chernobyl. Lancet Diabetes Endocrinol 2016, 4(8):647. http://www.sciencedirect.com/science/article/pii/S2213858716301127?via%3Dihub

メッセージ

We are aimed at designing and conducting laboratory and epidemiological research into the contribution of inherited genetic variations and somatic genetic alterations to the etiology of human cancer and non-cancer diseases, particularly focusing on populations exposed to radiation in Chernobyl, Kazakhstan and Japan to improve public health through gaining new insights into gene-environmental interactions.

Chris Fook Sheng Ng 准教授

    修了課程: 修了年度:

取得学位・資格

BSc, MAppStats, PhD

Research gate/Linked-in アカウント

https://orcid.org/0000-0003-1025-0807
https://www.researchgate.net/profile/Chris_Fook_Sheng_Ng
Contact Chris at https://tinyurl.com/yc3chlms

所属

School of Tropical Medicine and Global Health, Nagasaki University, Japan

経歴

Chris received his Bachelor of Science from the University of Nebraska-Lincoln (USA) (2002), a Master of Applied Statistics with distinction from the University of Malaya (Malaysia) (2005), and a PhD in Health Science from the University of Tokyo (Japan) (2011) for research on statistical method to measure the relative performance of post-market treatments in the absence of suitable controls. Following completion of his PhD, he went on to hold a postdoctoral position at the National Institute for Environmental Studies (Japan) where he studied the health effects of ambient temperatures and air pollution in Japan. In 2013, he became a postdoctoral fellow under the Japan Society for the Promotion of Science and expanded his work on environmental pollution and health to the developing countries in the tropics. He continued his work as an assistant professor at the Institute of Tropical Medicine, Nagasaki University (Japan), from late 2015 until early 2018. From April 2018, he joined the School of Tropical Medicine and Global Health at the same university as an Associate Professor. He was a Rutherford Fellow at the London School of Hygiene and Tropical Medicine (United Kingdom) between August 2018 to January 2019.

教育活動

Chris teaches biostatistics at the School of Tropical Medicine and Global Health at Nagasaki University, and previously, the School of International Health at the University of Tokyo. He has previously organized and taught undergraduate courses in statistics, actuarial mathematics, and quantitative analysis.

研究活動

Chris is interested in environmental epidemiology and the related statistical methods. His research focuses on the assessment of human health risk associated with atmospheric exposures such as air pollution, ambient temperatures, airborne pollen, and intercontinental dust events. He is currently leading a project to measure the health impacts of landscape fires that affect the air quality of many Southeast Asian cities. He is involved in a project that investigates the associations of fine particulate matter, its chemical constituents and sources with the lung function of asthma patients. He is also leading a study to examine the forward displacement of daily mortality attributable to air temperatures in tropical setting.

Given his extensive training in applied statistics, Chris is also interested in the application of statistics in a multidisciplinary context involving other health fields and looks forward to working with researchers from different backgrounds.

現在の主な研究活動地域

  • Japan
  • Malaysia
  • Philippines
  • Vietnam

最近の5つの出版物

  1. Ng CFS, Boeckmann M, Ueda K, Zeeb H, Nitta H, Watanabe C, Honda Y. Heat-related mortality: effect modification and adaptation in Japan from 1972 to 2010. Global Environmental Change. 2016; 39: 234-243.
  2. Ng CFS, Stickley A, Konishi S, Watanabe C. Ambient air pollution and suicide in Tokyo, 2001-2011. Journal of Affective Disorders. 2016; 201: 194-202.
  3. Konishi S, Ng CFS, Stickley A, Nishihata S, Shinsugi C, Ueda K, Takami A, Watanabe C (2014). Particulate matter modifies the association between airborne pollen and daily medical consultations for pollinosis in Tokyo. Science of the Total Environment. 2014; 499: 125-132.
  4. Ng CFS, Ueda K, Takeuchi A, Nitta H, Konishi S, Bagrowicz R, Watanabe C, Takami A. Socio-geographic variation in the effects of heat and cold on daily mortality in Japan. Journal of Epidemiology. 2014; 24(1): 15-24.
  5. Ng CFS, Ueda K, Ono M, Nitta H, Takami A. Characterizing the effect of summer temperature on heat-stroke-related emergency ambulance dispatches in the Kanto area of Japan. International Journal of Biometeorology. 2014; 58(5): 941-948.

メッセージ

In the digital age where data are collected faster and greater in quantity, strong quantitative skills are important to allow one to extract useful information from data. Statistics is central to this process. As you begin your journey with us, there will be opportunities to gain knowledge in statistical inference and develop skills in data analysis and interpretation. You will also be exposed to the data-driven approaches in epidemiology. I look forward to meeting students and researchers interested in utilizing these skills to improve health.

増田 研 准教授

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PhD in Social Anthropology

ResearchGate/LinkedInアカウント

https://www.linkedin.com/pub/ken-masuda/27/763/a83

他所属

School of Global Humanities and Social Sciences, Nagasaki University

経歴

Socio-anthropological study on history, socio-cultural dynamics, inter-ethnic conflict, modernization and development among the Banna in southern Ethiopia since 1993. Study on medical anthropology and medical pluralism since 2008. Study on population aging and elderly care since 2012.

教育活動

  • Teaching medical anthropology at TMGH and supervising master thesis at the International Health Development program. My students have carried out researches in Ethiopia, Kenya, Burkina Faso, Bangladesh, the Philippines, and Cambodia.
  • Teaching Environmental anthropology at the Faculty of Environmental Studies and African Study at the School of Global Humanities and Social Sciences.

研究活動

I am currently involved in research teams on global aging, especially focusing on future aging and social welfare in Africa. Both qualitative and quantitative research on elderly life, health, care and social protection will be carried out in East Africa; Ethiopia, Kenya, Uganda, and Zambia.

現在の主な研究活動地域

  • Ethiopia (1993-Now)
  • Kenya (2012-Now)
  • Tanzania (2015-Now)
  • Nagasaki (2004- Now)

メッセージ

1993年から北東アフリカのエチオピアに渡り,南部の少数民族バンナで,まさに現在進行中の近代化プロセスを研究してきました。辺境の小規模社会がグローバルなシステムに接続し,呑み込まれていく様子を見ていると,開発の良い面も悪い面も見えてきます。このコースでは伝統文化と社会のあり方,近代化と開発,そして「医学的でないやり方」について考えながら,人類学的な国際保健へのアプローチを教えています。

松井 三明 准教授

    修了課程: 修了年度:

取得学位・資格

MD, MSc, PhD

ResearchGate/LinkedInアカウント

mmatsui@nagasaki-u.ac.jp

経歴

I have been working in the field of maternal health. Pregnancy and childbirth are mostly physiological processes. In some cases, however, there are pathological aspects as well. Both physiology and pathology must be taken into account when considering maternal health. Unfortunately, only pathological phenomenon is focused on, as exemplified in the saying that “Every pregnancy is a risk”. Therefore, there is a huge misuse of medical interventions observed, both in developing and industrialized countries. We should strive to find an optimal point in between the two, keeping in mind that that point is variable. There is no “magic bullet” in the field of public health. We must think together how we can change this world.

教育活動

I am in charge of the two following modules

  • “Reproductive Health and Gender”Objective: to obtain necessary knowledge in order to control maternal morbidity and mortality and gender issues in developing countries.
  • “Program and Project Management”Objective: to obtain necessary knowledge and skill to manage public health program/projects in developing countries.

研究活動

  • “The impact of the improvement of the quality of care in maternity on maternal and neonatal health in health centers in Cambodia.”Outline – Evidence-based maternity and neonatal care is not well provided at health facilities in many developing countries, therefore the quality of care is substandard. However, international societies put immense pressure on the promotion of facility-based delivery regardless of the quality of care. We carry out an evaluation of maternal and neonatal conditions during labor and the postpartum period and observe the changes after an intervention, which aims to improve the quality of care during maternity.
  • “Factors of chronic malnutrition among children under 2 years old in rural Cambodia.”Outline – Approximately one out of four children aged 24 months demonstrated being “underweight” (weight for age < -2 s.d.) in rural Cambodia. This rate progressively increased with the age of the children. This study employs a prospective design to observe the changes of weight related to age and its associated factors in rural Cambodia.

現在の主な研究活動地域

Cambodia (capital – Phnom Penh, rural – Prey Veng province)

最近の5つの出版物

  1. Suto M, Takehara K, Misago C, Matsui M. Prevalence of perineal lacerations in women giving birth at midwife-led birth centers in Japan: A retrospective descriptive study. J midwife women health. in press(2015)
  2. Noguchi M, Matsui M, Osanai Y, Horikoshi Y, Takehara K, Misago C. Women-friendly childbirth experience Cambodia. J Int Health 29(4): 81.(2014)
  3. Matsui M, Sokhan U, Keth LS, Tung R.Equity gap in utilisation of emergency obstetric care service in Cambodia, from 2007 to 2009. Trop Med Int Health. 18(suppl 1): 187.(2013)
  4. Iwamoto A, Matsui M, Okabayashi H. Review of maternal, neonatal and child health integrated services in the southern four provinces in Lao PDR. Trop Med Int Health. 18(suppl 1): 186.(2013)
  5. Honda A, Randaoharison PG, Matsui M. Affordability of emergency obstetric and neonatal care at public hospitals in Madagascar. Reprod Health Matters. 19: 10-20.(2011)

メッセージ

開発途上国での妊娠,出産を安全にすること,また産む女性,生まれてくる子ども,そして家族にとってより良いものにしていくことを研究課題としています。
妊娠と出産は生理学的な事象ですが,時に合併症を伴います。よって正常から異常までの広い範囲に対応することが必要です。これらの対応とは,単に医学的なものだけではなく,次世代へ生をつなげようとする人々への、さらには社会に対しての関わりであり,そこに携わるひとりひとりの姿勢,ありようが問われるものです。
公衆衛生に関わるということは,すなわちクリアカットには割り切れない「社会的存在」としての人間の課題に取り組むことであり,この点に学問のおもしろさがあるのです。

Richard Culleton 准教授

    修了課程: 修了年度:

取得学位・資格

PhD in malaria parasite genetics

個人/所属ウェブページ

http://www.tm.nagasaki-u.ac.jp/malariaunit/Culleton_Lab/Home.html

ResearchGateアカウント

https://www.researchgate.net/profile/Richard_Culleton

LinkedInアカウント

https://www.linkedin.com/in/richardculleton/

Twitter

https://twitter.com/malariaunit?lang=en

他所属

Malaria Unit, Institute of Tropical Medicine, Nagasaki University

経歴

  • BSc (hons) Biological Sciences — University of Edinburgh, Scotland 1996-2000
  • PhD Malaria Parasite Genetics — University of Edinburgh, Scotland 2001 -2004
  • Research Assistant – University of Edinburgh – 2000 -2001
  • Research Associate – University of Edinburgh – 2004 -2005
  • International Research Fellow – Osaka University – 2005 -2008
  • Assistant Professor – Institute of Tropical Medicine, Nagasaki University – 2008 -2011
  • Associate Professor – Malaria Unit, ITM, Nagasaki University – 2011-Present

研究活動

My lab focuses on genetic and genomic approaches to identify the underlying genetic causes of medically important phenotypic differences between parasite strains. We use the rodent malaria parasites for some of these studies, but we are increasingly pursuing investigations involving the human malaria parasites in in vitro culture, and non-human primate malaria parasites such as Plasmodium cynomolgi in monkeys. We also work in malaria endemic countries on epidemiology related projects, including with P. falciparum and P. vivax in Africa, P. knowlesi and P. cynomolgi in Southeast Asia, and P. simium and P. brasilianum in South America. We are interested in ALL aspects of malariology.

現在の主な研究活動地域

  • Japan
  • Nigeria
  • Brazil

最近の5つの出版物

  1. Lu F, Culleton R, Zhang M, Ramaprasad A, von Seidlein L, Zhou H, Zhu G, Tang J, Liu Y, Wang W, Cao Y, Xu S, Gu Y, Li J, Zhang C, Gao Q, Menard D, Pain A, Yang H, Zhang Q & Cao J., Emergence of Indigenous Artemisinin Resistant Plasmodium falciparum in AfricaNew England Journal of Medicine 376 (10), 991-993 2017
  2. Abkallo H, Martinelli A, Inoue M, Ramaprasad A, Xangsayarath P, Gitaka J, Tang J, Yahata K, Zoungrana A, Mitaka H, Hunt P, Carter R, Kaneko O, Mustonen V, Illingworth CJR, Pain A & Culleton R, Rapid Identification of Genes Controlling Virulence and Immunity in Malaria ParasitesPLoS Pathogens 13(7): e1006447 2017
  3. Brasil P, Zalis MG, de Pina-Costa A, Siqueira AM, Bianco Junior C, Silva S, Areas ALL, Pelajo-Machado M, de Alvarenga DAM, Santelli ACFdS, Albuquerque HG, Cravo P, de Abreu FVS, Peterka CL, Zanini GM, Suarez-Mutis MC, Pissinatti A, Lourenco-de-Oliveira R, Brito CFAd, Ferreira-da-Cruz MdF, Culleton R, Daniel-Ribeiro CT. 2017. Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigationThe Lancet Global Health 5: e1038–46 2017
  4. Ansari HA, Templeton JT, Subudhi AK, Ramaprasad A, Tang J, Lu J, Naeem R, Oguike MC, Benavente ED, Clark TG, Sutherland CJ, Barnwell JW, Culleton R*, Cao J* and Pain A*. Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium speciesInternational Journal for Parasitology 2016 Oct; 46 (11) :685-96 2016 2016
  5. Abkallo HM, Tangena JA, Tang J, Kobayashi N, Inoue M, Zoungrana A, Colegrave N, Culleton R, Within-host competition does not select for virulence in malaria parasites; studies with Plasmodium yoelii PLOS Pathogens 11(2): e1004628 2015

For an up to date publication list, please see:
https://scholar.google.com/citations?user=Vkx8HZwAAAAJ&hl=en

メッセージ

The Malaria Unit at the Institute of Tropical Medicine is a dynamic and cosmopolitan laboratory specializing in the genetics and epidemiology of malaria. Although we take our scientific research very seriously, we endeavour to create a fun and relaxing environment for lab members, as we believe that science should be enjoyable and rewarding for the researcher.
We work on multiple disciplines within malariology, and try to accommodate each individual lab member’s research interests. We rely on a large network of international collaborators for the vast majority of our research projects, and currently have active partnerships with researchers in numerous regions including the UK, Portugal, Saudi Arabia, Brazil, Nigeria, Kenya, Thailand and elsewhere.
All research and lab life is conducted in English (with a smattering of Swahili, Welsh and American).
Our lab offers graduate students a relaxed and informal atmosphere in which to explore their own research interests with strong academic support and guidance if required.
Potential projects available with our lab include (but are not limited to); studies of inter-species interactions between malaria parasite strains and species within mice and mosquitoes; discovery of genes involved in drug resistance/ virulence/ strain-specific immunity in rodent malaria parasites through genetic crossing and whole genome sequencing; studies involving investigation of the conditions required for optimal vectorial capacity in mosquitoes; studies on the population genetics of P. falciparum, P. malariae and P. ovale in field isolates from Nigeria.
We also strongly encourage potential graduate students to design their own research utilizing the resources of the Malaria Unit. These include the largest collection of rodent malaria parasite isolates in the world, a colony of A. stephensi mosquitoes in a state-of-the-art insectary for transmission experiments, and access to field isolates from our international collaborators.

和田 崇之 准教授

    修了課程: 修了年度:

取得学位・資格

博士(医学)

個人/所属ウェブページ

http://www.tm.nagasaki-u.ac.jp/newrect/japanese/member/wada.html

他所属

長崎大学熱帯医学研究所国際保健学分野

経歴

  • 1997/3 京都大学理学部 卒業
  • 1999/3 京都大学大学院理学研究科生物物理学科前期課程 修了
  • 2006/12 大阪市立大学大学院医学研究科 博士(医学) 取得
  • 1999/4 – 2009/3 大阪市立環境科学研究所 研究員
  • 2009/4 – 2012/12 同 主任研究員
  • 2013/1 – 2017/4 長崎大学熱帯医学研究所国際保健学分野 国際保健学分野 助教
  • 2017/5 – 同 准教授

教育活動

(これまでの経験)
・学部講義(教養)感染症と文明
生物学基礎、生態学的観点と病原体について概説
・結核分子疫学
地方衛生研究所、保健所を対象に結核対策を指向した病原体遺伝子解析について解説、実習

研究活動

分子疫学、地域公衆衛生

病原体遺伝子情報(ゲノミクス、バイオインフォマティクス)と患者情報(疫学、地理統計学)を基盤とした病原体伝播経路の追跡。結核、抗酸菌症、その他細菌感染症。

動物感染症、人獣共通感染症における病原体適応進化

獣医学、生態学領域と連携し、動物由来試料からの病原体分離、遺伝子比較から病原体の適応進化戦略を理解する。腸内細菌叢、細菌性下痢症、その他宿主認識に関わる病原体因子。
以上の2点を中心に、時系列、地理拡散、宿主適応の3つのベクトルにおける病原体(特に細菌)のふるまいを俯瞰し、基礎・応用いずれにおいても意義のある研究成果を目指す。また、これらの研究を通して培った研究技術を基に、柔軟な社会貢献を希求する。

現在の主な研究活動地域

  • 日本
  • 台湾
  • ネパール

最近の5つの出版物

  1. 和田崇之, 吉田志緒美, 柳井徳磨. 2017. ヒト,動物,環境をとりまく非結核性抗酸菌の浸淫状況と宿主適応. 日本臨床微生物学雑誌 27: 1-10.
  2. Seto, J., Wada, T., Suzuki, Y., Ikeda, T., Mizuta, K., Yamamoto, T., Ahiko, T. 2017. Mycobacterium tuberculosis transmission among elderly persons, Yamagata Prefecture, Japan, 2009–2015. Emerg Infect Dis 23: 448-455.(2017)
  3. Ban, E., Yoshida, Y., Wakushima, M., Wajima, T., Hamabata, T., Ichikawa, N., Abe, H., Horiguchi, Y., Hara-Kudo, Y., Kage-Nakadai, E., Yamamoto, T., Wada, T., Nishikawa, Y. 2015. Characterization of unstable pEntYN10 from enterotoxigenic Escherichia coli (ETEC) O169:H41. Virulence 6: 735–744.(2015)
  4. Wada, T., Iwamoto, T., Tamaru, A., Seto, J., Ahiko, T., Yamamoto, K., Hase, A., Maeda, S., Yamamoto, T. 2015. Clonality and micro-diversity of a nationwide spreading genotype of Mycobacterium tuberculosis in Japan. PLoS ONE 10: e0118495.(2015)
  5. Wada, T., Iwamoto, T., Maeda, S. 2009. Genetic diversity of the Mycobacterium tuberculosis Beijing family in East Asia revealed through refined population structure analysis. FEMS microbiology letters 291: 35-43.(2009)

メッセージ

熱帯医学は典型的な応用科学、境界医学の一つと捉えることができますが、それだけに固執すると大事なことを見落とすかもしれません。TMGHの門を叩く学生は、もとより応用面への志が高いものと思いますので、特に基礎自然科学への親和性が高く、フレキシブルな志向を持てる学生を歓迎します。

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