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稲岡 健 ダニエル 助教

    修了課程: 修了年度:

取得学位・資格

薬学博士

ResearchGateアカウント

https://www.researchgate.net/profile/Daniel_Inaoka

他所属

東京大学医学系研究科・生物医化学教室・客員研究員

経歴

稲岡 健ダニエル博士(薬学)は2000年にブラジル東北部に位置するUniversidade Federal do Rio Grande do Norteで薬学部を卒業し、2000年から2005年の期間で東京大学薬学系研究科の修士及び博士課程を修了した。その後、東京大学医学系研究科で2007年までJSPS外国人特別研究員、2007年から2016年まで同研究科で助教として在籍した。長崎大学TMGHには2016年から助教(卓越)として赴任している。

教育活動

2002年から2005年まで、帝京大学医学部・物理学の非常勤講師として実習を担当。また、2007年から2016年まで東京大学医学系研究科・国際保健学専攻で生化学実習を担当した。長崎大学・TMGHではBasic Human Biologyの講義を北先生・神谷先生と共に講義を行う。

研究活動

稲岡は大学院でシャーガス病を引き起こすTrypanosoma cruziのピリミジン・エネルギー代謝経路の研究を行い、生化学・生物物理学・分子生物学・構造生物学・ケミカルバイオロジーといった手法を駆使して基礎研究及び創薬研究を行ってきた。外国人特別研究員・助教となってからは、分野を広げアフリカ睡眠病を引き起こすT. bruceiやリーシュマニア症を引き起こすLeishmania spp、熱帯熱マラリアを引き起こすPlasmodium falciparum等の寄生原虫の他、ブタ回虫(Ascaris suum)、アニサキス(Anisakis spp)、捻転胃虫(Haemonchus contortus)、肝蛭(Fasciola spp)、等の蠕虫で行われる微好気的エネルギー代謝の研究とそれによって支えられている寄生現象の分子機構を明らかにするための研究を行っている。その他にSATREPSプログラム「インドネシアの生物資源多様性を利用した抗マラリア・抗アメーバ新規薬剤リード化合物の探索」の研究分担者として、インドネシアで研究・実験の指導を行っている。対象疾患は幅広く、「寄生虫」、「ミトコンドリア」、「宿主環境適応」、「ユビキノン」、「エネルギー代謝」、「生化学」、「薬剤標的」、「薬剤開発」といったキーワードを基盤とした研究活動を行っている。

現在の主な研究活動地域

  • 日本
  • インドネシア
  • エル・サルバドル

最近の5つの出版物

  1. Hartuti ED, Inaoka DK (Corresponding Author, CA), Komatsuya K, Miyazaki Y, Miller RJ, Xinying W, Sadikin M, Prabandari EE, Waluyo D, Kuroda M, Amalia E, Matsuo Y, Nugroho NB, Saimoto H, Pramisandi A, Watanabe YI, Mori M, Shiomi K, Balogun EO, Shiba T, Harada S, Nozaki T, Kita K. Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Biochim Biophys Acta. 2018 Mar;1859(3):191-200.
  2. Wang X, Inaoka DK (CA), Shiba T, Balogun EO, Allmann S, Watanabe YI, Boshart M, Kita K, Harada S. Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Protein Expr Purif. 2017 Oct;138:56-62.
  3. Inaoka DK, Iida M, Hashimoto S, Tabuchi T, Kuranaga T, Balogun EO, Honma T, Tanaka A, Harada S, Nara T, Kita K, Inoue M. Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. Bioorg Med Chem. 2017 Feb 15;25(4):1465-1470.
  4. Inaoka DK (CA), Iida M, Tabuchi T, Honma T, Lee N, Hashimoto S, Matsuoka S, Kuranaga T, Sato K, Shiba T, Sakamoto K, Balogun EO, Suzuki S, Nara T, Rocha JR, Montanari CA, Tanaka A, Inoue M, Kita K, Harada S. The Open Form Inducer Approach for Structure-Based Drug Design. PLoS One. 2016 Nov 28;11(11):e0167078.
  5. Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S. Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria. Int J Mol Sci. 2015 Jul 7;16(7):15287-308.

古賀 智裕 助教

    修了課程: 修了年度:

取得学位・資格

  • 医学博士(長崎大学)
  • 医師免許

個人/所属ウェブページ

http://www.med.nagasaki-u.ac.jp/intmed-1/

ResearchGateアカウント

https://www.researchgate.net/profile/Tomohiro_Koga

他所属

  • 長崎大学病院第一内科(リウマチ・膠原病内科)
  • 長崎大学病院医療教育開発センター

経歴

  • 2005年4月~2009年3月 独立行政法人国立病院機構 長崎医療センター
  • 2009年4月~2011年5月 長崎大学病院 第一内科 リウマチ・膠原病内科 医員
  • 2011年6月~2014年2月 ハーバード医科大学(Beth Israel Deaconess Medical Center, Rheumatology Division, Dr.Tsokos Lab)
  • 2014年3月~2016年11月 長崎大学病院 医療教育開発センター 助教2016年12月〜現在 長崎大学大学院医歯薬学総合研究科 分子標的医学研究センター 助教(平成28年度科学技術人材育成費補助事業「卓越研究員事業」卓越研究員)

教育活動

  • 診断学:膠原病 各論実習
  • 研修医教育
  • 指導医講習会世話人

研究活動

  • 自己免疫疾患におけるT細胞シグナル伝達に関する研究
  • 自己炎症性疾患における遺伝子解析、サイトカイン解析に関する研究

現在の主な研究活動地域

日本

最近の5つの出版物

  1. Umeda M, Koga T (corresponding author), Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri SY, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y, Kawakami A. CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus. Clin Immunol. 2017 Oct 13. pii: S1521-6616(17)30567-3.
  2. Koga T, Kawashiri SY, Migita K, Sato S, Umeda M, Fukui S, Nishino A, Nonaka F, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Eguchi K, Kawakami A. Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients. Scand J Rheumatol. 2017 Sep 2:1-3. doi: 10.1080/03009742.2017.1363281.
  3. Koga T, Otomo K, Mizui M, Yoshida N, Umeda M, Ichinose K, Kawakami A, Tsokos GC. Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases. Arthritis Rheumatol. 2016 Aug;68(8):1981-8. doi: 10.1002/art.39665.
  4. Otomo K, Koga T (co-first author), Mizui M, Yoshida N, Kriegel C, Bickerton S, Fahmy TM, Tsokos GC. Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice. J Immunol. 2015 Dec 15;195(12):5533-7. doi: 10.4049/jimmunol.1501603.
  5. Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC. CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.

メッセージ

研究者の目を持つ臨床医としてリウマチ膠原病内科医としてクリニカルクエスチョンを基に、最終的には患者さんに還元し実用化可能な研究を行っています。希少難病とされる自己免疫疾患や自己炎症性疾患のアンメット・メディカル・ニーズを解決するため、ともに研究できる仲間を募集しています。

佐藤 美穂 助教

    修了課程: 修了年度:

取得学位・資格

MA, MPH, PhD

経歴

I earned an MA in anthropology in 1998 with a focus on development anthropology (a discipline within anthropology to apply anthropological perspectives in international development). After earning my MA, I joined Japan’s Network for Women and Health, a Japanese NGO. I was actively engaged in advocacy for sexual and reproductive health and rights. Then, as an MSH-HANDS Iwamura Fellow, I worked for the Advance Africa project, a USAID funded FP/HIV integration project in sub-Saharan Africa based in the US. After the Iwamura fellowship, I spent the next four years in Afghanistan, where I worked with Afghan and international colleagues to rebuild Afghanistan’s healthcare system. In 2010, I obtained an MPH from the University of Washington, and in 2011, I joined the faculty of Nagasaki University. In addition to education activities in Nagasaki and research work, I am also engaged in international cooperation projects, including From 2012 to 2014, I was involved in a JICA Project for Capacity Development in Regional Health Management Phase 2 in Tanzania (2012-2014), a JICA Project for Improvement of Services at Village Health Centers in Rural Host Community of Syrian Refugees (,2016 – 2018), and Maternal, Newborn and Child Health One Stop Service Project (2014-2017) as well as its follow-on, Promotion of Women’s Health throughout the Life Cycle at One Stop Service Site in Zambia (2018-2020).

教育活動

  • I will behave been coordinating a short-term field trip program during the spring quarter. Previous MPH students visited Bangladesh and the Philippines, where various achievements were made in the health sector, including the reduction of total fertility rate from 6.3 births per women in 1971 to 2.2 in 2013. Seeing model practices will provide students with the opportunity to connect with what they learned in previous semesters quarters as well as a basis to make comparisons with future studies studies/activities in the field.
  • In addition to the field trip, I will be teaching the gender part of the Reproductive Health and Gender classmodule, in which students will be trained to rethink their research project from a “gender lens”.

研究活動

  • In Ethiopia, I conducted a qualitative study of one local association/NGO which introduces people who seek a holy water cure to biomedical care. To date, this has been regarded as taboo by the Ethiopian Orthodox Christian religion.
  • In Tanzania, I was the Principal Investigator of the study which involved community representatives to take part in the district’s annual health planning process. Involvement of the representatives of the communities has been neglected in the district health planning processes, and this study examined whether this intervention would make a difference in the number of community-led public health activities, improve the services provided at health facilities, and motivate health workers.

現在の主な研究活動地域

  • Ethiopia
  • Tanzania

最近の5つの出版物

  1. 佐藤美穂. “エイズと聖水 -HIVの治療活動に携わるNGOの活動-”.国家支配と民衆の力 -エチオピアにおける国家・NGO・草の根社会-.宮脇幸生編.大阪公立大学共同出版会.p. 151-183.(2018)
  2. Sato M, Maufi D, Mwingira UJ, Leshabari MT, Ohnishi M, Honda S. Measuring three aspects of motivation among health workers at primary level health facilities in rural Tanzania. PloS one. May 5;12(5):e0176973.(2017)
  3. Sato, M, B.W. Giorgis, G. O’Malley. Barriers to and Factors Facilitating Adherence to Antiretroviral Therapy from the Perspectives of Patients in Mäqälä City, Tigray Region, Ethiopia. Nilo-Ethiopian Studies, 21: 15-28.(2016)

メッセージ

是非皆さんにはMPH取得以外にも2年間で達成すべき個人の目標を立てほしいと思います。自分のキャリア・ゴールを設定したり,また10年~15年後の自分の将来像を思い描くと目標が設定しやすくなるでしょう。2年は瞬く間に過ぎ去っていきます。皆さんがそれぞれの目標達成のために,長崎大学のリソースを最大限に活用されることを願っています。

樋泉 道子 助教

    修了課程: 修了年度:

取得学位・資格

  • MD
  • MTM
  • PhD

個人/所属ウェブページ

http://www.tm.nagasaki-u.ac.jp/pediatric/

他所属

Department of Pediatric Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University

経歴

I graduated from Kumamoto University Medical School, Japan and then had worked as a pediatrician for 8 years. Following that, I had studied tropical medicine and pediatric infectious diseases in the Master course of Tropical Medicine and in the Doctoral course in Graduate School of Biomedical Sciences, Nagasaki University. After I received my PhD, I joined the Department of Pediatric Infectious Diseases, the Institute of Tropical Medicine, Nagasaki University as an assistant professor in 2015.

教育活動

Facilitator of Epidemiology-Statistics Course in School of Tropical Medicine and Global Health, Nagasaki University

研究活動

Studies on pediatric infectious diseases in Vietnam:
Acute respiratory infections (incidence, viral/bacterial pathogens, risk factors)
Congenital infections (e.g.,rubella, CMV, Zika) and the effect on child development
Pneumococcal conjugate vaccine reduced dosing trial

現在の主な研究活動地域

ベトナム

最近の5つの出版物

  1. Michiko Toizumi, Motoi Suzuki, Hien Anh Thi Nguyen, Minh Nhat Le, Koya Ariyoshi, Hiroyuki Moriuchi, Masahiro Hashizume, Duc Anh Dang, and Lay-Myint Yoshida
    Viral Acute Respiratory Illnesses in Young Infants Increase the Risk of Respiratory Readmission
    The Pediatric Infectious Disease Journal, in press
  2. Imai, C., Toizumi, M., Hall, L., Lambert, S., Halton, K., Merollini, K.
    A systematic review and meta-analysis of the direct epidemiological and economic effects of seasonal influenza vaccination on healthcare workers
    (2018) PLoS ONE, 13 (6), art. no. e0198685
  3. Toizumi, M., Nguyen, G.T.H., Motomura, H., Nguyen, T.H., Pham, E., Kaneko, K.-I., Uematsu, M., Nguyen, H.A.T., Dang, D.A., Hashizume, M., Yoshida, L.-M., Moriuchi, H.
    Sensory defects and developmental delay among children with congenital rubella syndrome
    (2017) Scientific Reports, 7, art. no. 46483.
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017447271&doi=10.1038%2fsrep46483&partnerID=40&md5=e4958d50959615e2658576c987ed1bc9
    DOI: 10.1038/srep46483
  4. Yoshihara, K., Le, M.N., Okamoto, M., Wadagni, A.C.A., Nguyen, H.A., Toizumi, M., Pham, E., Suzuki, M., Nguyen, A.T.T., Oshitani, H., Ariyoshi, K., Moriuchi, H., Hashizume, M., Dang, D.A., Yoshida, L.-M.
    Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam
    (2016) Scientific Reports, 6, art. no. 27856.
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975155668&doi=10.1038%2fsrep27856&partnerID=40&md5=762505b0e9f3febd2b4412a119cb6ba8
    DOI: 10.1038/srep27856
  5. Yamanashi, H., Ngoc, M.Q., Van Huy, T., Suzuki, M., Tsujino, A., Toizumi, M., Takahashi, K., Thiem, V.D., Anh, D.D., Anh, N.T.H., Tho, L.H., Maeda, T., Cox, S.E., Yoshida, L.-M., Ariyoshi, K.
    Population-based incidence rates of first-ever stroke in central Vietnam
    (2016) PLoS ONE, 11 (8), art. no. e0160665.
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983475347&doi=10.1371%2fjournal.pone.0160665&partnerID=40&md5=ffb48a6308a404bd39460f8ddd42f7ab
    DOI: 10.1371/journal.pone.0160665

メッセージ

Please join us if you are interested in our researches on pediatric infectious diseases!

Bhim Gopal Dhoubhadel 助教

    修了課程: 修了年度:

取得学位・資格

MBBS, MTM, PhD

ResearchGate/LinkedInアカウント

Twitterアカウント

https://twitter.com/bhim_gopal

経歴

I received my medical degree from BP Koirala Institute of Health Sciences (BPKIHS), Nepal in 2005 and then worked for three years in paediatric hospitals in Nepal followed by one year in a refugee camp for Somali and Ethiopian refugees under UNHCR in Djibouti. Between 2010-11, I completed the Master of Tropical Medicine (MTM) programme in the Institute of Tropical Medicine, Nagasaki University and then a PhD in the Department of Clinical Medicine of the same institute between 2011 and 2014. In 2014, I was a Fellow of the Global (Health) Leadership Program at the University of Tokyo and completed an internship at the headquarters of the World Health Organization (WHO) in Geneva. My research interests are infectious diseases, child health and development of new diagnostic assays. In 2014, we established a new diagnostic assay for serotyping the pneumococcus (a major cause of pneumonia). The assay can identify vaccine serotypes easily and conveniently at a relatively low cost and has been applied in studies in Japan, Vietnam and Afghanistan.

教育活動

At TMGH, I teach master students about essential skills and tropical medicine (clinical bacteriology and molecular diagnostic technique), and organize and facilitate clinical case discussion between the students and doctors in San Lazaro Hospital (Philippians), Bach Mai Hospital (Vietnam) and National Center for Global Health and Medicine (Japan).

Previously I taught advanced paediatric life support (APLS) course to junior medical doctors in Siddhartha Children and Women Hospital, Nepal and child health and management of malnutrition to medical and nursing staffs in Djibouti.

研究活動

I have studied the distribution of pneumococcal serotypes in hospital admitted children and adults in Japan, Vietnam and Afghanistan with a particular focus on the estimation of pneumococcal vaccine coverage.

After I participated in relief efforts following the earthquake in 2015 in Nepal, we are developing a research collaboration with Siddhi Memorial Hospital, Bhaktapur (http://smf.org.np). The focus is on childhood infectious diseases and malnutrition. We are supporting hospital disease surveillance and have conducted nutritional assessments of children who were displaced by the earthquake and living under temporary shelters.

At TMGH, we are establishing new diagnostic assays for typhoid fever based on real-time PCR and loop-mediated isothermal amplification (LAMP). We plan to evaluate these assays in Nepal and other field sites.

bhim_1
Picture1:Disease surveillance in Siddhi Memorial Hospital, Bhaktapur, Nepal.


bhim_2
Picture 2: Nutritional assessment of children in temporary shelters in Bhaktapur after 2015 earthquake in Nepal.


現在の主な研究活動地域

  • Japan
  • Nepal
  • Afghanistan

最近の5つの出版物

  1. Kakiuchi S, Suzuki M, Dhoubhadel BG, Furumoto A, Ito H, Kei Matsuki, Tsuchihashi Y, Asoh N, Yasunami M, Ariyoshi K, Morimoto K, Adult Pneumonia Study Group-Japan (2018). Accuracy of high-throughput nanofluidic PCR-based pneumococcal serotyping and quantification assays using sputum samples for diagnosing vaccine serotype pneumococcal pneumonia: analyses by composite diagnostic standards and Bayesian latent class models, J Clin Microbiol.
  2. Shrestha D, Dhoubhadel BG, Parry CM, Prajapati B, Ariyoshi K, Mahaseth C (2017). Predicting deaths in a resource-limited neonatal intensive care unit in Nepal, Trans R Soc Trop Med Hyg.
  3. Zabihullah R, Dhoubhadel BG, Rauf RA, Shafiq SA, Suzuki M, Watanabe K, Yoshida LM, Yasunami M, Zabihullah S, Parry CM, Mirwais R, Ariyoshi K (2017). Risk for death among children with pneumonia, Afghanistan, Emerg Infect Dis.
  4. Suzuki M, Dhoubhadel BG, Ishifuji T, Yasunami M, Yaegashi M, Asoh N, Ishida M, Hamaguchi S, Aoshima M, Ariyoshi K, Morimoto K; Adult Pneumonia Study Group-Japan (APSG-J) (2016). Serotype-specific effectiveness of the 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia among adults aged ≥65 years: a multicenter prospective test-negative design study, Lancet Infect Dis.
  5. Dhoubhadel BG, Yasunami M, Nguyen HA, Suzuki M, Vu TH, Thi Thuy Nguyen A, Dang DA, Yoshida LM, Ariyoshi K (2014) Bacterial Load of Pneumococcal Serotypes Correlates with Their Prevalence and Multiple Serotypes is Associated with Acute Respiratory Infections, PLoS One.

すべての出版物へのリンク

http://www.ncbi.nlm.nih.gov/sites/myncbi/1pMFjL8tdMn55/bibliography/40287257/public/?sort=date&direction=ascending

メッセージ

Clinical infectious diseases, child health and vaccination are some of the inter-related exciting fields of global health.
We have been working in these areas and found that there are lots to discover, learn and contribute on these topics globally.
We hope you will find them interesting and contribute while you study here at TMGH. Welcome!

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