Associate Professor Daniel Ken Inaoka
Speciality / Research theme / KeywordsTumour Biology, Molecular Biology, Structural Biology, Medicinal Chemistry, Parasitology
SupervisionMasters ProgrammeDoctoral Programme
PhD, Pharmaceutical Sciences
Research gate account links
Visiting Researcher, Department of Biomedical Chemistry, School of International Health, Graduate School of Medicine, The University of Tokyo.
I was born and lived 21 years in Brazil, an endemic country for Chagas disease and Leishmaniasis. I studied at the Faculty of Pharmacy from Universidade Federal do Rio Grande do Norte. In 2000, I came to Japan and under the support of Mombukagakusho Scholarship I obtained Master and PhD degree in Pharmaceutical Sciences at Graduate School of Pharmaceutical Sciences, The University of Tokyo. During my Master and Doctoral course I have analyzed the biochemical and structural biological properties of dihydroorotate dehydrogenase, a potential drug target from Trypanosoma cruzi involved in pyrimidine de novo biosynthesis. In 2005, I moved to Graduate School of Medicine, The University of Tokyo supported by Postdoctoral Fellowships for Foreign Researchers (JSPS) to start research in structural biology and drug design targeting the unique energy metabolism found in Trypanosomatids and Helminthes. Since 2007, I become Assistant Professor of Department of Biomedical Chemistry from Graduate School of Medicine at The University of Tokyo to research molecular and biochemical parasitology and drug design targeting enzymes involved in microaerophilic mitochondrial metabolism from protozoan parasites and helminthes. I have expertise in the field of biochemistry, parasite metabolism, structural biology and drug design.
I worked as part-time lecturer for practical class in biophysics at Teikyo University, between 2002 and 2005. I was also in charge of practical class in biochemistry at School of International Health, The University of Tokyo, from 2007 to 2016. At TMGH, Nagasaki University, I will be teaching part of Basic Human Biology coordinated by Prof. Kita and Prof. Kamiya.
Based in keywords such as “Parasite”, “Mitochondria”, “Host Environment Adaptation”, “Ubiquinone”, “Energy Metabolism”, “Biochemistry”, “Drug Target” and “Drug Development”, my current research area include Trypanosomatids and Apicomplexan parasites, Helminthes and Tumor Microenvironment.
The country/countries where you work currently
- El Salvador
Five MOST IMPORTANT/INTERESTING recent publications
- Hartuti ED, Inaoka DK (Corresponding Author, CA), Komatsuya K, Miyazaki Y, Miller RJ, Xinying W, Sadikin M, Prabandari EE, Waluyo D, Kuroda M, Amalia E, Matsuo Y, Nugroho NB, Saimoto H, Pramisandi A, Watanabe YI, Mori M, Shiomi K, Balogun EO, Shiba T, Harada S, Nozaki T, Kita K. Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Biochim Biophys Acta. 2018 Mar;1859(3):191-200.
- Wang X, Inaoka DK (CA), Shiba T, Balogun EO, Allmann S, Watanabe YI, Boshart M, Kita K, Harada S. Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Protein Expr Purif. 2017 Oct;138:56-62.
- Inaoka DK, Iida M, Hashimoto S, Tabuchi T, Kuranaga T, Balogun EO, Honma T, Tanaka A, Harada S, Nara T, Kita K, Inoue M. Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. Bioorg Med Chem. 2017 Feb 15;25(4):1465-1470.
- Inaoka DK (CA), Iida M, Tabuchi T, Honma T, Lee N, Hashimoto S, Matsuoka S, Kuranaga T, Sato K, Shiba T, Sakamoto K, Balogun EO, Suzuki S, Nara T, Rocha JR, Montanari CA, Tanaka A, Inoue M, Kita K, Harada S. The Open Form Inducer Approach for Structure-Based Drug Design. PLoS One. 2016 Nov 28;11(11):e0167078.
- Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S. Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria. Int J Mol Sci. 2015 Jul 7;16(7):15287-308.