Sharon Cox教授

Professor Sharon Cox

sharon_cox_01

Qualifications

  • BSc (Hons), MSc, PhD

Personal/work Web page addresses

Research gate or Linked-in account links

Twitter account name

  • @sharonecox15

Affiliation(s)

  • Graduate School of Tropical Medicine & Global Health, Nagasaki University, Japan
    global_gealth_logo
  • London School of Hygiene & Tropical Medicine, London. UK
    london_school_logo

Background

  • I graduated from University College London with a BSc. (Biochemistry, First Class Hons) in 1996, followed by a postgraduate teaching qualification (1997), a Masters in Public Health Nutrition at the London School of Hygiene & Tropical Medicine [LSHTM] (1998) and finally a PhD, also at LSHTM (2003). My PhD comprised a clinical trial of low-dose maternal vitamin A supplementation to determine effects on immunity to malaria in pregnancy in Ghana. In 2002 I became a staff member at LSHTM within the MRC International Nutrition Group and worked on malaria and anemia in Gambian children. In 2007 I moved to be based in Dar es Salaam Tanzania, working mostly on sickle cell disease. In 2015 I was appointed as a Professor at the School of Tropical Medicine & Global Health, Nagasaki, where I am now based. I also hold a joint appointment at LSHTM.

Teaching

  • I co-organise courses in Epidemiology and statistics in semesters 1 and 3 for the TMGH MSc courses.. These courses are based on those provided by the London School of Hygiene & Tropical Medicine masters programmes and are taught by Nagasaki and visiting LSHTM research staff. I also teach individual sessions on topics including Nutrition and Global Health and effects of both under and over-nutrition, nutrition and infection, epidemiology and field-based research methodology and sickle cell disease in Africa.
  • Previously at the London School of Hygiene & Tropical Medicine, UK I taught and managed units within the MSc in Public Health Nutrition and I have been a tutor on distance based learning MSc courses: “Nutrition and Infection” & “Study Design: writing a grant application”.

Research

  • I am conducting research on nutrition in TB patients in the Philippines, with new studies starting in 2016 and collaborating with investigators form San Lazaro Hospital, Manila and the Nutrition Centre, Philippines. The aim of this research is to investigate how nutrition and nutritional management may determine outcomes of infectious diseases like TB and malaria.
  • Research in Nepal on the prevalence of malnutrition in pediatric admissions, with the aim of developing simple interventions to improve nutritional management and prevention of malnutrition in patients with moderate or mild malnutrition co-morbidity.
  • Research in The Gambia and Vietnam on the predictors of development of hypertension and vascular dysfunction.
  • I am also involved in ongoing research on malaria elimination strategies and impacts on maternal and child health in Western Kenya, with collaborators from Osaka City University & Karolinska Institute, (Prof Akira Kaneko).
  • Research on the causes and management of anemia in hospital and community based settings in Kenya.
  • I am also continuing my research in sickle cell disease (outlined below).
  • I have been working with the Muhimbili Sickle Cohort in Tanzania, comprising over 4,000 patients in routine follow-up and the Muhimbili Wellcome Programme since 2007. My research has focused on nutritional and genetic modulation of sickle cell disease (SCD). We recently completed a Wellcome Trust funded clinical trial of a nutraceutical intervention in children with SCD with primary endpoints of growth and improved vascular function. The data are currently being analysed. My main collaborators in MWP are Dr Julie Makani, (Muhimbili University of Health & Allied Sciences & University of Oxford) & Professor Charles Newton (University of Oxford & KEMRI-Kilifi, Kenya).sharon_cox_document01Assessing vascular function in Tanzanian children with sickle cell disease as part of the Vascular Function Intervention Trial (V-FIT).sharon_cox_document02Measuring body composition (body fat% & fat free mass) using a Tanita Bioimpedance device.

The country/countries where you work currently

  • Tanzania
  • Kenya
  • The Gambia
  • Vietnam
  • The Philippines
  • Nepal
  • UK
  • Japan

Five MOST IMPORTANT/INTERESTING recent publications

2015 Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir AY, Wielders JP, Mens PF, Verweij JJ, Cox SE, Prentice AM, Brouwer ID, Savelkoul HF, Andang’o PE, Verhoef H. Effect of Daily Antenatal Iron Supplementation on plasmodium Infection in Kenyan women: A Randomized Clinical Trial. JAMA. 2015 Sep 8;314(10):1009-20.
2014 Pasricha S, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, Tijhaar E, Verhoef H, Prentice AM, Drakesmith A. Hepcidin expression distinguishes types of anaemia in African children. Science Trans Med: 6; 235re3.
2013 L’Esperance VS*, Cox SE*, Simpson D*, Gill C, Makani J, Soka D, Mgaya J, Kirkham FJ, Clough GF. Peripheral vascular response to inspiratory gasp in pediatric sickle cell anemia. Exp Physiol; 98: 49-56 [*shared first authorship]
2011 Cox SE, Makani J, Komba AN, Soka D, Newton CR, Kirkham FJ & Prentice AM. Global arginine bioavailability in Tanzanian sickle cell patients at steady state:A nested case control study of deaths vs survivors. Brit J Haematol; 155: 522-4
2011 Cox SE, Makani J, Fulford AJ, Komba AN, Soka D, Williams TN, Newton CR, Marsh K, Prentice AM. Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania. Haematologica; 96: 948-53.

Link to all publications

http://www.ncbi.nlm.nih.gov/sites/myncbi/1tmZEPnoXym/bibliography/40021911/public/?sort=date&direction=ascendinga

メッセージ

I propose that nutrition is one of the most important modifiable environmental factors underlying health and disease. Along with infections such as malaria, nutrition has been one of the strongest selection pressures over our recent evolutionary history. This has significant implications in relation to the rapid changes in diet and lifestyle that are occurring globally. Under and over-nutrition are increasingly occurring within the same population groups and in both low and high-income countries.
Nutrition is essential to consider at individual and community/population levels in order to ensure that health interventions are optimally successful.
My research focuses on understanding the mechanisms by which nutritional factors affect health outcomes, with a focus on low- and middle-income country settings and encompassing infectious and non-infectious disease processes.

PAGETOP