Professor Osamu Kaneko

Professor Osamu Kaneko

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Qualifications

  • MD, PhD

Personal/work Web page addresses

Research gate or Linked-in account links

Affiliation(s)

  • Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.
  • Department of Medical Protozoology, Graduate School of Biomedical Sciences, Nagasaki University, Japan

Background

  • I graduated from Osaka City University Medical School, Japan in 1990 and then trained as an Orthopedic Surgeon for 2 years. Following that, I decided to spend 4 years studying malaria in Osaka City University’s Graduate School of Medicine. After I received my PhD, I worked in the Laboratory of Parasitic Diseases (Louis H. Miller Lab), NIAID, NIH, USA from 1997 to 1999. In 2000, I became a faculty member in the Department of Molecular Parasitology (Prof. Motomi Torii Lab), Ehime University School of Medicine, Japan and joined the Institute of Tropical Medicine, Nagasaki University as a full time professor in 2007. I was inspired to study malaria by the Prof. Kazuyuki Tanabe’s lecture in 1986. For more details, please read my memoir of Kazuyuki Tanabe published in Paraisotl Int (2014).

Teaching

  • School of Tropical Medicine and Global HealthI am responsible for lectures and practices on Medical Protozoology, including malaria, African trypanosomiasis (sleeping sickness), American trypanosomiasis (Chagas disease), leishmaniasis, and intestinal protozoan infections.
  • Other teachings at Nagasaki University
    • Training course of Tropical MedicineI am responsible for lectures and practices on Medical Protozoology.
    • Liberal arts Education “Safety and Security of the Medical Field”I give lectures on Medical Protozoology.
    • School of Medical Sciences, School of Medicine (Medical Microbiology and Parasitology)I give lectures and guide practices on Medical Protozoology.
    • Graduate School of Biomedical Sciences (Infectious Diseases)- I am responsible for lectures (Medical Parasitology) and thesis research in the Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases (TECD).- I am responsible for seminars, practices, and thesis research in the Program alongside TECD.

Research

  • Malaria is a huge burden and responsible for many deaths in large areas of the tropical and sub-tropical world. In order to design and implement effective disease intervention strategies, I believe that one of the key priorities in malaria research should be the strengthening of our understanding of the basic biology of the parasite. My team is currently investigating some fundamental aspects of the parasite’s life cycle, such as the mechanisms behind red blood cell (RBC) invasion and the phenomenon of cytoadherence of parasite-infected RBCs using human malaria parasite Plasmodium falciparum, monkey malaria parasite P. knowlesi and rodent malaria parasite P. yoelii. I am also engaged in the field studies conducted in Thailand to understand the P. vivax biology in collaboration with Dr. Jetsumon Sattabongkot (Mahidol Vivax Research Center, Faculty of Tropical Medicine, Mahidol University, Thailand) and molecular epidemiology of P. falciparum in Kenya in collaboration with Prof. Akira Kaneko (Department of Parasitology, Osaka City University, Japan). Recently, we started to conduct a research to establish novel malaria model using ungulate malaria parasites.kaneko_osamu_document01RBC invasion by P. yoelii. Merozoite-stage parasite (arrowhead) invades into RBC within 30 seconds (0 – 25 s) and deformed RBC to spike-like shape (85 s).kaneko_osamu_document02Recombinant protein (green) expressed in P. falciparum co-localized with Maurer’s cleft protein (red) seen in the RBC cytosol outside of the malaria parasite. Nucleus is visualized with blue color.

The country/countries where you work currently

  • Thailand
  • Kenya

Five MOST IMPORTANT/INTERESTING recent publications

2018 Kegawa Y, Asada M, Ishizaki T, Yahata K, Kaneko O. Critical role of Erythrocyte Binding-Like protein of the rodent malaria parasite Plasmodium yoelii to establish an irreversible connection with the erythrocyte during invasion. Parasito Int (in press)
2018 Asare KK, Sakaguchi M, Lucky AB, Asada M, Miyazaki S, Katakai Y, Kawai S, Song C, Murata K, Yahata K, Kaneko O. The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan’s clefts in the infected erythrocyte. Parasitol Int 67:481-92. [Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29673877]
2018 Kaewthamasorn M, Takeda M, Saiwichai T, Gitaka JN, Tiawsirisup S, Imasato Y, Mossaad E, Sarani A, Kaewlamun W, Channumsin M, Chaiworakul S, Katepongpun W, Teeveerapunya S, Panthong J, Mureithi DK, Bawm S, Htun LL, Win MM, Ismail AA, Ibrahim AM, Suganuma K, Hakimi H, Nakao R, Katakura K, Asada M, Kaneko O. Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host. Sci Rep 8:5827 [Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29643434]
2016 Templeton TJ, Asada M, Jiratanh M, Ishikawa SA, Tiawsirisup S, Sivakumar T, Namangala B, Takeda M, Mohkaew K, Ngamjituea S, Inoue N, Sugimoto C, Inagaki Y, Suzuki Y, Yokoyama N, Kaewthamasorn M, Kaneko O. Ungulate malaria parasites. Sci Rep 6:23230. [Abstract]
2016 Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+ monitoring in Plasmodium falciparumusing the yellow cameleon-Nano biosensor. Sci Rep 6:23454.[Abstract]

Message

When I was a medical student, I visited many tropical and subtropical countries and recognized that infectious diseases were still huge burdens in the world. Then, one day in a parasitology class, I learned that the disease malaria was a major problem, and thereafter I was fascinated by malaria and its causative pathogen, Plasmodium. Now I am conducting research to elucidate the molecular mechanism of host cell invasion and modification mechanisms by this parasite, toward finding weak points to combat the disease malaria.

 

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