INFORMATION

Blog Archives

Professor and Dean Kiyoshi Kita

    COURSES: YEAR:

Qualifications

PhD (Pharmacy), Pharmacist

Personal/work Web page addresses

http://www.tmgh.nagasaki-u.ac.jp/about_tmgh/dean

Background

I was educated at Department of Biological Sciences, The University of Tokyo, and gradated in 1980. I joined Department of Biological Sciences, The University of Tokyo as assistant professor (1980 – 1983), and moved to Department of Parasitology, Juntendo University, School of Medicine (1983). Later, I was promoted to lecturer (1987-1990). Then, promoted to associate professor of Department of Parasitology, The Institute of Medical Science, The University of Tokyo (1991-1998). In 1998, I was appointed as Professor Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo and retired in 2016. In 2015, I was appointed as Dean of TMGH by cross-appointment system between The University of Tokyo and Nagasaki University.

Teaching

Giving lectures (Biochemistry of metabolism, Drug development and Molecular Parasitology) in Nagasaki University and other Universities.

Research

Biochemistry of metabolism of pathogens and drug development.

The country/countries where you work currently

Japan, Central and South America, Southeast Asia, Africa, USA and Europe.

Five MOST IMPORTANT/INTERESTING recent publications

  1. In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. Yoshino, R., Yasuo, N., Hagiwara, Y., Ishida, T., Inaoka, D.K., Amano, Y., Tateishi, Y., Ohno, K., Namatame, I., Niimi, T., Orita, M., Kita, K., Akiyama, Y. & Sekijima, M. (2017) Sci. Rep. 7, 6666
  2. Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Wang, X., Inaoka, D.K., Shiba T., Balogun, E.O., Allmann, S., Watanabe, Y., Boshart, M., Kita, K. & Harada, S. (2017) Protein Expr. Purif. 138, 56-62
  3. Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity. Balogun, E.O., Inaoka, D.K., Shiba, T., Tokuoka, S.M., Tokumasu, F., Sakamoto, K., Kido, Y., Michels, P.A.M., Watanabe, Y., Harada, S. & Kita K.
    (2017) Biochim. Biophys. Acta (General Subjects) 1861, 2830-2842
  4. Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Hartuti, E.D., Inaoka, D.K., Komatsuya, K., Miyazaki, Y., Miller, R.J., Xinying, W., Sadikin, M., Prabandari, E.E., Waluyo, D., Kuroda, M., Amalia, E., Matsuo, Y., Nugroho, N.B., Saimoto, H., Pramisandi, A., Watanabe, Y., Mori, M., Shiomi, K., Balogun, E.O., Shiba, T., Harada, S., Nozaki, T. & Kita K. (2018) Biochim. Biophys. Acta (Biogentics) 1859, 191-200.
  5. Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Yamashita, T., Inaoka, D.K., Shiba, T., Oohashi, T., Iwata, S., Yagi, T., Kosaka, H., Miyoshi, H., Harada, S., Kita, K. & Hirano, K. (2018) Sci. Rep. 8, 2427

Message

Contribution from basic research in Japan to the health and wellfare of the people in the world.

Professor Kiyoshi Aoyagi

    COURSES: YEAR:

Qualifications

PhD

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/public-h/staff/index.html

Affiliation(s)

Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences

Background

  • 1979 – 1985 – Nagasaki University School of Medicine (undergraduate)
  • 1989 – 1989 – Nagasaki University Graduate School of Medicine
  • 1989 Nagasaki University Hospital (Orthopedics)
  • 1989 Tagawa City Hospital (Orthopedics)
  • 1991 Kitakyushu General Hospital (Orthopedics)
  • 1993 Mitsugi General Hospital (Orthopedics)
  • 1995 Hawaii Osteoporosis Center (Research fellow)
  • 1996 Nagasaki University Hospital (Orthopedics)
  • 1997 Public Health, Nagasaki University School of Medicine
  • 2002 Professor, Public Health, Nagasaki University Graduate School of Biomedical Sciences 2007 Professor, Graduate School of International Health Development Nagasaki University

Teaching

  • 1998 – present – Medical care & Public Health
  • 2001 – present – Thesis Research on Public Health
  • 2001 – present – Seminar on Public Health
  • 2001 – present – Practice on Public Health
  • 2002 – 2003 – First-year Seminar
  • 2004 – 2009 – Health Science
  • 2007 – 2014 – Environmental Health
  • 2012 – 2014 – Nutrition and Health

Research

  • Epidemiology of bone health and lifestyle-related disease
  • Statistical analysis of rheumatoid arthritis

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Fukushima A, Aoyagi K, Eguchi K, Kawakami A. Combination of MRI-detected bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability of early rheumatoid arthritis. Ann Rheum Dis 73:2219-2220,(2014)
  2. Kitahara H, Ye Z, Aoyagi K, Ross PD, Abe Y, Honda S, Kanagae M, Mizukami S, Kusano Y, Tomita M, Shindo H, Osaki M. Associations of vertebral deformities and osteoarthritis with back pain among Japanese women: the Hizen-Oshima study. Osteoporos Int. 24(3):907-915,(2013)
  3. Osaki M, Tatsuki K, Hashikawa T, Norimatsu T, Chiba K, Motokawa S, Furuichi I, Doiguchi Y, Aoyagi K, Shindo H. Beneficial effect of risedronate for preventing recurrent hip fracture in the elderly Japanese women. Osteoporosis Int 23(2): 695-703,(2012)
  4. Tamai M, Kawakami A, Iwamoto N, Kawashiri SY, Fujikawa K, Aramaki T, Kita J, Okada A, Koga T, Arima K, Kamachi M, Yamasaki S, Nakamura H, Ida H, Origuchi T, Aoyagi K, Uetani M, Eguchi K.Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by MRI of wrist and finger joints and physical examination, Arthritis Care Res, 63(3):436-439(2011)
  5. Abe Y, Takamura N, Ye Z, Tomita M, Osaki M, Kusano Y, Nakamura T, Aoyagi K, Honda S.Quantitative ultrasound and radiographic absorptiometry are associated with vertebral deformity in Japanese Women:the Hizen-Oshima study.Osteoporos Int, 22(4):1167-1173(2010)

Message

Tropical medicine generally concerns developing countries and the problems of community health and disease. In the class, we also cover the basic concepts of public health, policies and measures. In the process of “health transition”, many developing countries have an aging population with a growing number of patients exhibiting heart/cerebrovascular disease and malignant tumors, while traditional infectious diseases are yet to be overcome. In Japan, on the other hand, deaths from infectious diseases have declined, while non-infectious diseases such as heart/cerebrovascular diseases and malignant tumors account for 60% of deaths. We study Japan’s past public health policies and current and future public health measures so as to draw lessons for application to developing countries.

Professor of Clinical Medicine Koya Ariyoshi

    COURSES: YEAR:

Qualifications

M.D.(Japan), DTM&H (London), MSc Clinical Tropical Medicine (London), PhD (U.K.)

Personal/work Web page addresses

http://www.tm.nagasaki-u.ac.jp/internal/nekkennaika.htm

Contact

kari@nagasaki-u.ac.jp

Affiliation(s)

  • Department of Clinical Medicine, Institute of Tropical Medicine (NEKKEN)
  • Department of Infectious Diseases, Nagasaki University Hospital
  • School of Tropical Medicine and Global Health, Nagasaki University
  • Honorary Professor, Clinical Research Department, Faculty of Infectious Tropical Medicine, London School of Tropical Medicine and Hygiene, UK

Background

I had my residency training in internal medicine in Tokyo, 1986-1988. From those days I was interested in working in Africa, which let me do DTMH in London, followed by a post-graduate clinical training in Harare Central Hospital, Zimbabwe, 1989 where I encountered my life work, AIDS. My master project on HIV viral load at LSHTM in 1990 was very successful that I was offered a job as a clinical research fellow at the Jefferiss Wing, St. Mary’s Hospital. My asset of multi-disciplinary human-network has been established when working in London, Oxford and West Africa for 8 years as well as in Tokyo at NIID for 3 years and in Thailand for JICA for 4 years.

Teaching

I am the course director of Master of Tropical Medicine (MTM) where I teach clinical tropical medicine, malaria and non-malaria febrile illness, STD and HIV/AIDS. I also facilitate the tropical infectious disease case discussion.

As a chief of NEKKEN training/education center, I also organize the three-month diploma course of tropical medicine.

Research

HIV research had been a core of my carrier before joining NEKKEN. It broadened my skills to understand a disease from multidisciplinary aspects such as behavioral, epidemiological, clinical science, molecular immunology and virology. Most of my work has derived from clinical-epidemiology settings such as cohort or case-control studies. I enjoy digging out clinical research questions by seeing patients and discussing with medical professionals. On joining to the current group of NEKKEN, my research topic has been broaden toward pneumonia in low, middle and high-income countries, non-malarial febrile illness such as typhus, leptospirosis. Now we have on-going studies in infectious disease wards in North Vietnam, the Philippines and Japan.

ariyoshi_koya_document01Discussing in an overcrowded ward in Bac Mai Hospital, Vietnam with Dr. Thuy, one of the most experienced I.D. physicians.

The country/countries where you work currently

  • The Philippines
  • Vietnam
  • Thailand
  • Japan

Five MOST IMPORTANT/INTERESTING recent publications

Hyperlink to the NAOSITE of each paper will be posted if it is “open access”, so that viewers can jump straight to the text of the paper.

  1. Kitashoji E, Koizumi N, Lacuesta TLV, Usuda D, Ribo MR, Tria ES, Go WS, Kojiro M, Parry CM, Dimaano EM, Villarama JB, Ohnishi M, Suzuki M, Ariyoshi K. Diagnostic Accuracy of Recombinant immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines. PLoS Negl Trop Dis 9(6): e0003879.(2015)
  2. Morimoto K, Suzuki M, Ishifuji T, Yaegashi M, Asoh N, Hamashige N, Abe M, Aoshima M, Ariyoshi K; Adult Pneumonia Study Group-Japan (APSG-J). The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. PLoS One. 10(3): e0122247.(2015)
  3. Hamaguchi S, Cuong NC, Tra DT, Doan YH, Shimizu K, Tuan NQ, Yoshida LM, Mai LQ, Duc-Anh D, Ando S, Arikawa J, Parry CM, Ariyoshi K, Thuy PT. Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus Among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam. Am J Trop Med Hyg. pii: 14-0806.(2015)
  4. Dhoubhadel BG, Yasunami M, Nguyen HA, Suzuki M, Vu TH, Thi Thuy Nguyen A, Dang DA, Yoshida LM, Ariyoshi K. Bacterial load of pneumococcal serotypes correlates with their prevalence and multiple serotypes is associated with acute respiratory infections among children less than 5 years of age. PLoS One. 31;9(10):e110777.(2014)
  5. M Mori, N Wichukchinda, R Miyahara, A Rojanawiwat, P Pathipvanich, T Maekawa, T Miura, P Goulder, M Yasunami, K Ariyoshi, P. Sawanpanyalert. HLA-B*35:05 is a protective allele with a unique structure amongst HIV-1 CRF01_AE-infected Thais, where the B*57 frequency is low. AIDS ; 28(7): 959-67.(2014)

Link to other publications

http://www.ncbi.nlm.nih.gov/sites/myncbi/1n5JSXaavr65l/bibliography/48630402/public/?sort=date&direction=ascending

Message

My asset is a human-network developed while working as a AIDS-researcher and a clinician in the UK MRC Laboratories, The Gambia, West Africa for 6 years. I then spent 4 years in Thailand for a JICA-project on HIV/AIDS; since becoming a professor of Nagasaki University, developed various clinical-epidemiology research projects in Vietnam, the Philippines and Japan; also have a role in the infectious disease ward at the University Hospital. Head of center for training/education, NEKKEN; Deputy Dean of the School of Tropical Medicine and Global Health. Message for students: ” if you want to make a substantial impact on health in resource-constrained setting, you should work hard.”

Professor Koichi Izumikawa

    COURSES: YEAR:

Qualifications

M.D., PhD.

Personal/work Web page addresses

Research gate or Linked-in account links

http://www.researchgate.net/researcher/38153266_Koichi_Izumikawa

Affiliation(s)

  •  Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences (GSBS)
    http://www.tecd.prj.nagasaki-u.ac.jp/en/program/member.html
  • The American Society for Microbiology
  • The Japanese Society of Internal Medicine
  • The Japanese Respiratory Society
  • The Japanese Association for Infectious Diseases
  • The Japanese Society of Chemotherapy
  • The Japanese Society of Medical Mycology

Background

  • 1994 – Nagasaki Univ. School of Medicine, awarded MD
  • 2000 – Postgraduate School, Laboratory Medicine, Nagasaki University School of Medicine, awarded Ph.D.
  • 2003 – Clinical Mycology Section, LCI/NIAID, National Institutes of Health
  • 2005 – Assistant professor, Second Department of Internal Medicine, Nagasaki University School of Medicine
  • 2009 – Molecular Microbiology Section, LCID/NIAID, National Institutes of Health
  • 2009 – Assistant professor, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
  • 2011 – Senior Assistant professor, Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences
  • 2013 – Present – Director, Nagasaki University Hospital Infection Control and Education Center
  • 2014 – Present – Professor, Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

Teaching

  • Subject at TMGH:  Medical Microbiology III
  • Message to the students: Emerging and re-emerging diseases such as the Ebola virus disease in West African countries and the Dengue fever in Japan are becoming real threats and we do not know what comes next. I am involved in the management of patients with various infectious diseases as well as infection control at the Nagasaki University Hospital. Extensively high skills, knowledge and preparation are required for deadly infectious disease control. I can offer chances to learn the practical management of these infectious diseases in this course and hope to see many students.
  • Teaching at GSBS and Infectious Control and Education Center: Clinical Infectious Diseases Studies, Infectious Diseases Control and Infectious Diseases Studies

Research

  • Pathogenesis and drug resistance of fungi
  • Development of new diagnosing tools and treatment

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, Kullberg BJ, Lagrou K, Maertens J, Meis JF, Newton P, Page I, Seyedmousavi S, Sheppard DC, Viscoli C, Warris A, Donnelly JP.
    International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus.
    Drug Resist Updat. 2015 Jul-Aug;21-22:30-40. doi: 10.1016/j.drup.2015.08.001. Epub 2015 Aug 7.
  2.  Tashiro M, Izumikawa K, Ashizawa N,  Narukawa M, Yamamoto Y. Clinical significance of methicillin-resistant coagulase-negative staphylococci obtained from sterile specimens. Diagnostic Microbiology and Infectious Disease, 81(1), pp.71-75; 2015.
    http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/35001/1/DMID81_71.pdf
  3.  Izumikawa K, Watanabe A, Miyashita N, Ishida T, Hosono H, Kushimoto S, Kohno S. Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan. Journal of Infection and Chemotherapy, 20(9), pp.541-548; 2014.
    http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/34811/1/JIC20_541.pdf
  4. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M. The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan. J Infect Dis. 209(6), pp.816-827,2014
  5. Izumikawa K, Izumikawa KI, Takazono T, Kosai K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Yanagihara K, Hara K, Kohno S. Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: A review of the Japanese literature. Journal of Infection and Chemotherapy, 20(3), pp.181-185; 2014
    http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/34972/1/JIC20_181.pdf

Message

Emerging and re-emerging diseases are becoming real threats in the world and we do not know what comes next as well as when it happens. I am involved in the management of patients with various infectious diseases as well as infection control in Nagasaki University Hospital. Extensively high skills, knowledge and preparation are required for deadly infectious disease. I can offer chances to learn the practical management of these infectious diseases in this course and hope to see many students.

Professor Junko Okumura

    COURSES: YEAR:

Qualifications

Pharmacist, MPH (U of Michigan), PhD

Research gate or Linked-in account links

http://www.researchgate.net/profile/Junko_Okumura

Affiliation(s)

Nagasaki University, Institute of Tropical Medicine (Main work station).

Teaching

Please refer the TMGH Syllabus.

Research

Will be filled later

The country/countries where you work currently

  • Will be filled later
    You might also consider using a PubMed Bibliography Collection as it can be used to easily keep your publications up to date and provide a list of publication references, for example, for your CV or as a web link – please see below.
  • Please refer 6. Research gate.

Message

Fearing that I would regret that I did not accomplish anything, on an impulse I went to work overseas in the field where I realized how much I had to learn. I then entered graduate school at 37 years old and became a late-blooming researcher, despite the fact that I used to hate studying when I was young. To regret doing something or to regret not doing something, the choice is yours. You should find out solutions for development and health by yourself. Textbooks and classes are just tools which provide you with clues.

Professor Hiroki Ozawa

    COURSES: YEAR:

Qualifications

M.D., Ph.D.

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/psychtry/

Affiliation(s)

  • Division of Neuropsychiatry
  • Unit of Translational Medicine
  • Graduate School of Biomedical Sciences

Background

Education

  • 1985/03 School of Medicine, Sapporo Medical University
  • 1990/03 Ph.D. Graduate School of Medicine, Sapporo Medical University

Work

  • 1993/04-1999/12  Lecturer , Dept. Neuropsychiatry, Sapporo Medical University
  • 2000/01-2001/11 Assistant Professor, Dept. Neuropsychiatry, Sapporo Medical University
  • 2001/12-2004/09 Associate Professor, Dept. Neuropsychiatry, Sapporo Medical University
  • 2003/10 – pres.  Professor, Division of Neuropsychiatry, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University

Teaching

  • Psychiatry, Global mental health
  • mhGAP Intervention Guide for mental, neurological and substance use disorders in non-specialized health settings

Research

  • Our department executes a long-term investigation of epidemiology such as the prognosis of patients who suffer from schizophrenia, their mental and physical health conditions, which are caused by Atomic bomb or the eruption of Unzen Fugendake.
  • The molecule, inherited historical research and investigation on schizophrenia, and the cause of a causal mental disease such as Bi-polarity depression are the main streams of research in our department now.
  • In the latter researches we investigate the correlation of structural abnormality and the psychological illness of the brain, and examine how the mental disease medicine affects the neural stem cells. We try to connect the three of them.
  • For instance, about 10 percent of the victims from the disaster of the Fugendake eruption are still suffering from mental symptoms, on the other hand many of them have recovered from the disaster. In addition, the more that the treatment period is prolonged, the worse the prognosis of schizophrenia, therefore it is important that diagnosis and treatment are conducted as early as possible.
  • Using genetics and biological research, I would like to verify the factors in this epidemiologic study.

The country/countries where you work currently

  • China
  • Indonesia
  • Thai
  • Singapore
  • Myanmar

Message

In this laboratory, we are conducting researches on long-term outcomes for schizophrenic patients and the mental/physical health of victims of the atomic bombs and the disaster on Mt. Fugen.

Current main themes are the molecular/genetic study of schizophrenia and pathobiologic study to discover the causes of endogenous mental disorders including bipolar disorder.

In recent studies, I have been examining the effects of antipsychotic drugs on neural stem cells, studying the correlation between mental disorder and structural abnormality in the brain. In the future, I plan to establish a more academic research system by integrating these three studies.

For example, approx. 10% of the victims of the Mt. Fugen disaster still suffer from psychoneurosis, even though most of them have already recovered. Additionally, the prognosis of schizophrenia worsens as the treatment period lengthens, demonstrating the importance of early diagnosis and early treatment.

I intend to discover these factors in epidemiologic study through genetic and biological studies.

Professor Osamu Kaneko

    COURSES: YEAR:

Qualifications

MD, PhD

Personal/work Web page addresses

http://www.tm.nagasaki-u.ac.jp/protozoology/eng/

Research gate or Linked-in account links

http://www.researchgate.net/profile/Osamu_Kaneko2

Affiliation(s)

  • Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.
  • Department of Medical Protozoology, Graduate School of Biomedical Sciences, Nagasaki University, Japan

Background

I graduated from Osaka City University Medical School, Japan in 1990 and then trained as an Orthopedic Surgeon for 2 years. Following that, I decided to spend 4 years studying malaria in Osaka City University’s Graduate School of Medicine. After I received my PhD, I worked in the Laboratory of Parasitic Diseases (Louis H. Miller Lab), NIAID, NIH, USA from 1997 to 1999. In 2000, I became a faculty member in the Department of Molecular Parasitology (Prof. Motomi Torii Lab), Ehime University School of Medicine, Japan and joined the Institute of Tropical Medicine, Nagasaki University as a full time professor in 2007. I was inspired to study malaria by the Prof. Kazuyuki Tanabe’s lecture in 1986. For more details, please read my memoir of Kazuyuki Tanabe published in Paraisotl Int (2014).

Teaching

School of Tropical Medicine and Global Health

I am responsible for lectures and practices on Medical Protozoology, including malaria, African trypanosomiasis (sleeping sickness), American trypanosomiasis (Chagas disease), leishmaniasis, and intestinal protozoan infections.

Other teachings at Nagasaki University

  • Training course of Tropical MedicineI am responsible for lectures and practices on Medical Protozoology.
  • Liberal arts Education “Safety and Security of the Medical Field”I give lectures on Medical Protozoology.
  • School of Medical Sciences, School of Medicine (Medical Microbiology and Parasitology)I give lectures and guide practices on Medical Protozoology.
  • Graduate School of Biomedical Sciences (Infectious Diseases)- I am responsible for lectures (Medical Parasitology) and thesis research in the Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases (TECD).- I am responsible for seminars, practices, and thesis research in the Program alongside TECD.

Research

Malaria is a huge burden and responsible for many deaths in large areas of the tropical and sub-tropical world. In order to design and implement effective disease intervention strategies, I believe that one of the key priorities in malaria research should be the strengthening of our understanding of the basic biology of the parasite. My team is currently investigating some fundamental aspects of the parasite’s life cycle, such as the mechanisms behind red blood cell (RBC) invasion and the phenomenon of cytoadherence of parasite-infected RBCs using human malaria parasite Plasmodium falciparum, monkey malaria parasite P. knowlesi and rodent malaria parasite P. yoelii. I am also engaged in the field studies conducted in Thailand to understand the P. vivax biology in collaboration with Dr. Jetsumon Sattabongkot (Mahidol Vivax Research Center, Faculty of Tropical Medicine, Mahidol University, Thailand) and molecular epidemiology of P. falciparum in Kenya in collaboration with Prof. Akira Kaneko (Department of Parasitology, Osaka City University, Japan). Recently, we started to conduct a research to establish novel malaria model using ungulate malaria parasites.
kaneko_osamu_document01RBC invasion by P. yoelii. Merozoite-stage parasite (arrowhead) invades into RBC within 30 seconds (0 – 25 s) and deformed RBC to spike-like shape (85 s).kaneko_osamu_document02Recombinant protein (green) expressed in P. falciparum co-localized with Maurer’s cleft protein (red) seen in the RBC cytosol outside of the malaria parasite. Nucleus is visualized with blue color.

The country/countries where you work currently

  • Thailand
  • Kenya

Five MOST IMPORTANT/INTERESTING recent publications

  1. Kegawa Y, Asada M, Ishizaki T, Yahata K, Kaneko O. Critical role of Erythrocyte Binding-Like protein of the rodent malaria parasite Plasmodium yoelii to establish an irreversible connection with the erythrocyte during invasion. Parasito Int (in press)
  2. Asare KK, Sakaguchi M, Lucky AB, Asada M, Miyazaki S, Katakai Y, Kawai S, Song C, Murata K, Yahata K, Kaneko O. The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan’s clefts in the infected erythrocyte. Parasitol Int 67:481-92. [Abstract]
  3. Kaewthamasorn M, Takeda M, Saiwichai T, Gitaka JN, Tiawsirisup S, Imasato Y, Mossaad E, Sarani A, Kaewlamun W, Channumsin M, Chaiworakul S, Katepongpun W, Teeveerapunya S, Panthong J, Mureithi DK, Bawm S, Htun LL, Win MM, Ismail AA, Ibrahim AM, Suganuma K, Hakimi H, Nakao R, Katakura K, Asada M, Kaneko O. Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host. Sci Rep 8:5827 [Abstract]
  4. Templeton TJ, Asada M, Jiratanh M, Ishikawa SA, Tiawsirisup S, Sivakumar T, Namangala B, Takeda M, Mohkaew K, Ngamjituea S, Inoue N, Sugimoto C, Inagaki Y, Suzuki Y, Yokoyama N, Kaewthamasorn M, Kaneko O. Ungulate malaria parasites. Sci Rep 6:23230. [Abstract]
  5. Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+ monitoring in Plasmodium falciparumusing the yellow cameleon-Nano biosensor. Sci Rep 6:23454.[Abstract]

Message

When I was a medical student, I visited many tropical and subtropical countries and recognized that infectious diseases were still huge burdens in the world. Then, one day in a parasitology class, I learned that the disease malaria was a major problem, and thereafter I was fascinated by malaria and its causative pathogen, Plasmodium. Now I am conducting research to elucidate the molecular mechanism of host cell invasion and modification mechanisms by this parasite, toward finding weak points to combat the disease malaria.

Professor Satoshi Kaneko

    COURSES: YEAR:

Qualifications

M.D.,M.P.H.,Ph.D

Personal/work Web page addresses

Affiliation(s)

  • Institute of Tropical Medicine, Nagasaki University
  • Visiting lecturer of Tohoku University
  • Visiting scientist of Osaka Kyoiku University

Other titles

  • Associate Editor of Journal of Epidemiology
  • Councilor of Japanese Society of Tropical Medicine
  • JICA Consultant, Sri Lanka Non-communicable disease management project

Background

  • Graduated from the National Defense Medical College, Saitama, Japan in 1990
  • JICA expert in the Tropical Disease Control Project for Chagas disease in Guatemala in 1995
  • Master of Public Health (MPH) degree from Harvard School of Public Health, Boston, Massachusetts, U.S.A in 1997.
  • PhD degree from the Graduate School of Medical Science, University of Occupational and Environmental Health, JAPAN (UOEH), Kitakyushu, JAPAN in 2001
  • Head of Cancer Surveillance Section, Statistics and Cancer Control Division in National Cancer Center, Tokyo from 2001 until 2005
  • Professor (Fixed-term) at Institute of Tropical Medicine, Nagasaki University since 2005 to present (Between 2006 and 2010, appointed at Nairobi Research Station, Nagasaki University)
  • Professor at Nagasaki University Graduate School of International Health Development since 2008 to present

Teaching

  • Professor (Fixed-term) at Institute of Tropical Medicine, Nagasaki University since 2005 to present (Between 2006 and 2010, appointed at Nairobi Research Station, Nagasaki University)
  • Professor at Nagasaki University Graduate School of International Health Development since 2008 to present

Research

  • Development of microsphere-based simultaneous multiple assays and surveillance systems for multiple infectious diseases in Africa.
  • Health and Demographic Surveillance System (HDSS) in Lao PDR.
  • Epidemiological studies for child health in Kenya.
  • Research on dengue prevention through a residential environmental clean-up program in Sri Lanka.
  • Finding malaria vaccine candidate antigens using microsphere-based simultaneous multiple assays.
  • A scientific approach to community-led total sanitation strategies in Africa.
  • Non-communicable disease (NCD) project by JICA in Sri Lanka.
  • Developing epidemiological data-collection tools using the cutting edge IT technology to monitor health-related problems in developing world; e.g., biometrics (vein authentication) to identify people and link different data sources (link: here)

The country/countries where you work currently

  • Africa
  • Asia

Five MOST IMPORTANT/INTERESTING recent publications

  1. Shinsugi C, Matsumura M, Karama M, Tanaka J, Changoma M, Kaneko S. Factors associated with stunting among children according to the level of food insecurity in the household: a cross-sectional study in a rural community of Southeastern Kenya. BMC public health 2015; 15(1): 441-51.(2015)
  2. Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K. Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models. PLoS neglected tropical diseases 2014 Jul; 8(7): e3040.(2014)
  3. Miura M, Tanigawa C, Fujii Y, Kaneko S. Comparison of six commercially-available DNA polymerases for direct PCR. Rev Inst Med Trop Sao Paulo 2013 Nov-Dec; 55(6): 401-6.(2013)
  4. Kaneko S, K’Opiyo J, Kiche I, Wanyua S, Goto K, Tanaka J, Changoma M, Ndemwa M, Komazawa O, Karama M, Moji K, Shimada M. Health and Demographic Surveillance System in the Western and Coastal Areas of Kenya: An Infrastructure for Epidemiologic Studies in Africa. J Epidemiol 2012 Feb 25; 22(3): 276-85.(2012)
  5. Komazawa O, Kaneko S, K’Opiyo J, Kiche I, Wanyua S, Shimada M, Karama M. Are Long-Lasting Insecticidal Nets Effective for Preventing Childhood Deaths among Non-Net Users? A Community-Based Cohort Study in Western Kenya. PloS one 2012; 7(11): e49604.(2012)

Message

Learn on site. Everything starts there. What are the problems? What do we need to solve them? In order for us to solve problems, we need “knowledge” and “tools.” We also need to enthusiastically observe and dedicate ourselves to solving problems scientifically. Many of the problems we face do not have ready-made answers. This graduate course aims to establish a mechanism in which knowledge and tools from the “site” are applied to the “academic sphere,” and vice versa. Together, we learn, practice, develop research, and return to practice. Let us embark on our quest for the unknown world!

Professor Yasuhiko Kamiya

    COURSES: YEAR:

Qualifications

M.D., M.Trop.Paed., PhD

Research gate or Linked-in account links

https://www.researchgate.net/profile/Yasuhiko_Kamiya

Affiliation(s)

  • Graduate School of Tropical Medicine & Global Health, Nagasaki University, Japan
  • Nagasaki University Graduate School of Biomedical Sciences

Background

After acquiring MD. from Kochi Medical School in 1985, I worked for children with disability. I acquired Masters in Tropical Paediatrics from Liverpool School of Tropical Medicine in 1995, with the dissertation “ Pneumocystis Pneumonia in HIV infected children in Malawi”, and Ph.D. from Faculty of Medicine, University of Liverpool in 2002 with the thesis “Epidemiology and microbiology of acute respiratory infections in children in an urban poor area in Nairobi, Kenya and molecular epidemiology of RS virus”. I joined vaccine trials for pertussis and measles in Ghana. I worked for humanitarian assistance in the former Yugoslavia, the former Zaire, Iraq, Afghanistan, Honduras and South Sudan with AMDA, Peace Wind Japan, UNHCR, and UNICEF. I have consulted and coordinated on community health, health system strengthening, epidemiology on infectious diseases and NCD in Sri Lanka, Kenya, Ghana, Fiji and Philippines and for local capacity development for health system research and epidemiology.

Teaching

I will be teaching Global Health I, Child Health I, Child Health II, Community Health I, and Emergency Assistance I at the TMGH, and also supervising Long Term Internship for MPH course. Currently I am teaching child health and pediatric diseases in MTM and TTM courses, and current epidemiological transition and health system research at the phD Leading program. Previously I taught Overview of Global Health, Child Health, and Emergency Assistance at the Graduate School of International Health Development, along with supervision for long term internship for MPH students.

Research

I have been studying aid effectiveness, particularly on aid fragmentation and its effect on health system. I participated in randomized control trials for several vaccines in Ghana, and did clinical and microbiological (molecular biological) study on RS virus and pneumocystis pneumonia in Malawi, cohort study for ARI in children in Kenya and NCD especially cardiovascular diseases and diabetes in Sri Lanka as well as research on referral system in Ghana, and supervision and health information system in Kenya along with overuse of antibiotics, disease replacement under polymicrobial status. I am also engaged in study on access and seeking behavior in children with disability in the Philippines.

The country/countries where you work currently

  • Japan
  • Ghana
  • Kenya
  • Honduras
  • Philippines
  • Sri Lanka
  • South Sudan
  • India

Five MOST IMPORTANT/INTERESTING recent publications

  1. Tsukakoshi T, Samuela J, Rafai EV, Rabuatoka U, Honda S, Kamiya Y, Buerano CC, Morita K. Hepatitis B serologic survey and review of immunization cords of children, adolescents and adults in Fiji, 2008–2009. Virology Journal 2015, 12:36
  2. Kamiya Y. Epidemiology of infectious diseases in Africa in relation to polymicrobial replacement, urbanization, and control measures in health systems. Yves Charbit and Teiko Mishima (Eds.), Questions de migrations et de sante en Afrique Sub-saharienne (Issues of Migrations and Health in Sub-Saharan Africa). Recherches interdisciplinaires en France et au Japan. (pp. 187-213) 2014, Paris: L’ Harmattan.
  3. Masumoto S, Yamamoto T, Ohkado A, Yoshimatsu S, Querri AG, Kamiya Y. Prevalence and associated factors of depressive state among pulmonary tuberculosis patients in Manila, the Philippines. International Journal of Tubercle and Lung Disease. 2014. 18 (2) 174-179.
  4. Masumoto S, Yamamoto T, Ohkado A, Yoshimatsu S, Querri AG, Kamiya Y.. Factors associated with health-related quality of life among pulmonary tuberculosis patients in Manila, the Philippines. Quality of Life Research 2014 Jun;23(5):1523-1533.
  5. Sasaki E, Kamiya Y*. Caregivers’ Understanding of Pediatric Medication in Central Malawi. J Trop Pediatr. doi: 10.1093/tropej/fmu057 2014.

Message

In development assistance, you must clearly position yourself as to how you support and how much you intervene, while in humanitarian emergency aid, you must make difficult decisions promptly. The more you are involved, the more you realize the hollowness or limits of some approaches to international cooperation, the gap between ideals and reality, and the importance of learning from people in the field. To develop your capability along with those in the field, not necessarily solely for your career development, it is important to learn and un-learn some of what you have studied.

What is taught and learned in the classroom differs from what actually happens and is implemented. Sharing our failures and reflections in the field would be for beneficiaries, not for our carriers. This course offers the chance where we can continue our self-development together, with multifaceted perspectives and a critical regard for ourselves, while being aware of the privilege of mutually teaching and learning.

Professor Taro KIKUCHI

    COURSES: YEAR:

Qualifications

Bachelor of Economics from Waseda University, Japan

Background

  • 2017-, Current position
  • 2015-2017, Director in the Health Group, Japan International Cooperation Agency (JICA) Headquarters, Tokyo, supervising the health sector cooperative technical and financial projects with health ministry of the government in the counties located in the South and Southeast Asia, responsible for the monitoring of JICA global health strategy under Japan’s Official Development Assistance (ODA) policy on health, acting as the focal point of external relations in the areas of health and medicine with international financing institutions(e.g. the Asian Development Bank), United Nations Agencies (e.g. the World Health Organization), and global health initiatives(e.g. P4H Network for the Universal Health Coverage).
  • 2013-2015, Senior Representative, JICA Tunisia Office, Tunis, appointed for the Assistant Country Director on behalf of JICA in Tunisia.
  • 2010-2013, Advisor in the Health Group, JICA HQ, Tokyo, designing and managing the health sector assistances for some East Africa countries (including the technical cooperation of scientific research in partnership with the Nagasaki University in Kenya), planning and coordination of JICA’s health cooperation directions in alignment with the global health trend, and acting as the first contact about the international health agendas especially targeting the Africa (e.g. emerging infectious diseases and zoonosis).
  • 2008-2010, Assistant Director in the Africa Department, JICA HQ, Tokyo, managing the follow-up of the Fourth Tokyo International Conference on African Development(TICAD Ⅳ) and planning the process to TICAD Ⅴ in close collaboration with the Ministry of Foreign Affairs of Japan.
  • 2005-2008, Representative in charge of health sector, JICA Zambia Office, Lusaka, coordinating the JICA’s health-related activities ranging from Japanese health volunteers to technical cooperation under JICA country assistance strategy for Zambia, and serving as the Japan’s focal in health for accelerating the aid harmonization for enhanced effectiveness with major health development partners present in Zambia(e.g. the United States Agency for International Development, U.K. Department for International Development, the World Bank, WHO).
  • 1996-1998, Researcher, Grant Aid Division, Economic Cooperation Bureau, Ministry of Foreign Affairs, Tokyo, taking charge of humanitarian emergency assistances as Japan’s ODA including disaster relief and aid to the refugees in the forms of food and medical commodities supply, and financial supports to the countries in the post-conflict and social reconstruction phase.

Teaching

Foreign Aid Policy in health and facilitation of internships abroad.-Based on working experiences in the international development organization, theory of development assistance related to the global health issues, practical methods and administration in the management of bilateral cooperation under Japan’s ODA are offered at classes.-Students who willingly take internship program at Japan’s ODA projects are supported.

Research

>Focuses on how much effectively Japan’s ODA projects in the area of health is implemented and how much responsive they will be to the global health issues in the new era of the Sustainable Development Goals(SDGs)

The country/countries where you work currently

  • Bangladesh, Myanmar, Lao PDR and Thailand(Asia)
  • Used to work for the health sector in Kenya and Zambia(Africa)

Message

I am currently seconded from JICA (Japan International Cooperation Agency). The landscape around the global health is constantly dynamic. Timely response to the international heath always requires in-depth understanding of the discussion on the health challenges made at the global level and comprehension of the health policy framework developed at the national level. In addition, I suppose that international health professionals should outfitted with the competence to work out a plan on the field to sustainably ensure local people’s health. Health and Medicine are the promising area of development cooperation where Japan ably makes great contribution. I am looking forward to cultivating study, at the Nagasaki University, together with the TMGH students who expectedly become the health professionals in the way to combine my own working experiences with the class lessons and practical trainings.

Professor Christopher Smith

    COURSES: YEAR:

Qualifications

MRCP, MRCGP, MSc, PhD, DTM&H (East African Partnership)

Personal/work Web page addresses

https://www.lshtm.ac.uk/aboutus/people/smith.christopher

Research gate or Linked-in account links

https://www.linkedin.com/in/chris-smith-44580610/

Affiliation(s)

  • Graduate School of Tropical Medicine and Global Health, Nagasaki University
  • Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine

Background

I have a joint position between the Department of Clinical Research at LSHTM and the graduate school of Tropical Medicine and Global Health (TMGH) at Nagasaki University since September 2017. I have been working at LSHTM since 2014, funded by a Medical Research Council Population Scientist Fellowship. My main area of research is in the field of digital health interventions to support sexual and reproductive health

I completed my PhD titled ‘Increasing contraception use with mobile phone-based interventions’ at LSHTM in 2017 which included a systematic review of mHealth interventions for contraception and the MObile Technology for Improved Family Planning (MOTIF) trial in partnership with Marie Stopes International in Cambodia.

Previously I completed the Public Health in Developing Countries MSc at LSHTM in 2011 as part of a National Institute of Health Research (NIHR) In-Practice Fellowship based at Imperial College London during 2010-12.

I work as a primary care medical doctor (GP) in London and have worked on an NHS project with Maddox Jolie-Pitt foundation in Cambodia and with Medecins Sans Frontieres in Uganda.

Teaching

I co-organised the Family Planning programmes module (2401) at LSHTM for the last three years and teach at Nagasaki University. I supervise Masters and PhD students.

Research

Interventions delivered by mobile phone (digital/mHealth); sexual and reproductive health; primary care; health partnerships.I am principal investigator on a project to develop an intervention to support reproductive health in Cambodia together with collaborators at SOAS, Kings College London and Marie Stopes International, funded by the Arts and Humanities Research Council (AHRC).Selected publications can be accessed here in addition to the list below. Please contact me for further information or if you are interested to discuss research or PhD projects.

The country/countries where you work currently

  • Japan
  • United Kingdom
  • Cambodia
  • Philippines

Five MOST IMPORTANT/INTERESTING recent publications

  1. Kuhlin J, Smith C, Khaemraev A, Tigay Z, Parpieva N, Tillyashaykhov M, Achar J, Hajek J, Greig J, du Cros P, Moore D. The impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan. The International Journal of Tuberculosis and Lung Disease. 2018;22(5):544-550
  2. Smith C, Edwards P, Free C. Assessing the validity and reliability of self-report data on contraception use in the Mobile Technology for Improved Family Planning (MOTIF) randomised controlled trial. Reproductive Health. 2018;15:50
  3. Smith C, Ngo T, Gold G, Edwards P, Vannak U, Sokhey L, Machiyama K, Slaymaker E, Warnock R, McCarthy O, Free C. Effect of a mobile phone-based intervention on post-abortion contraception: a randomized controlled trial in Cambodia. Bulletin of the World Health Organization. 2015.
  4. Smith C, Gold J, Ngo T, Sumpter C, Free C. Mobile phone-based interventions for improving contraception use (Review). Cochrane Database Syst Rev. 2015;(6)
  5. Smith C, Pettigrew L, Seo H, Dorwood J. Combining General Practice with International work: experiences of UK GPs. J R Soc Med Sh Rep. 2012;3(46):1-9

Message

I am a clinical researcher with interests in different areas and experience of mixed methods research. I have worked as a primary care doctor in the UK and Uganda, where I recently completed the Professional Diploma in Tropical Medicine and Hygiene (DTM&H): East African partnership. My research has mainly been on digital health interventions for reproductive health, including a randomised controlled trial in Cambodia. Please contact me for further information or if you are interested to discuss research or PhD projects.

Professor Isao SHIMOKAWA

    COURSES: YEAR:

Professor Sharon Cox

    COURSES: YEAR:

Qualifications

BSc, MSc, PhD

Personal/work Web page addresses

http://www.lshtm.ac.uk/aboutus/people/cox.sharon

Research gate or Linked-in account links

https://www.researchgate.net/profile/Sharon_Cox

Twitter account name

@sharonecox15

Affiliation(s)

School of Tropical Medicine and Global Health, Nagasaki University, Japan
London School of Hygiene and Tropical Medicine, London, UK

Background

I graduated from University College London with a BSc. (Biochemistry, First Class Hons) in 1996, followed by a postgraduate teaching qualification (1997), a Masters in Public Health Nutrition at the London School of Hygiene & Tropical Medicine [LSHTM] (1998) and finally a PhD, also at LSHTM (2003). My PhD comprised a clinical trial of low-dose maternal vitamin A supplementation to determine effects on immunity to malaria in pregnancy in Ghana. In 2002 I became a staff member at LSHTM within the MRC International Nutrition Group and worked on malaria and anemia in Gambian children. In 2007 I moved to be based in Dar es Salaam Tanzania, working mostly on sickle cell disease. In 2015 I was appointed as a Professor at School of Tropical Medicine & Global Health, Nagasaki University, where I am now based. I also hold a joint appointment at LSHTM.

Teaching

I co-organise courses in Epidemiology and Statistics in semesters 1 and 3 for the TMGH MSc courses. These courses are based on those provided by the London School of Hygiene & Tropical Medicine masters programmes and are taught by Nagasaki and visiting LSHTM research staff. I also organise a module on Nutrition for Global Health in Semester 3 and teach individual sessions on in other modules on effects of both under and over-nutrition, diagnosis and management of acute malnutrition, nutrition and infection, causes and effects of anaemia in the tropics, epidemiology and field-based research methodology

Previously at the London School of Hygiene & Tropical Medicine, UK I taught and managed units within the MSc in Public Health Nutrition and I have been a tutor on distance based learning MSc courses: “Nutrition and Infection” & “Study Design: writing a grant application.

Research

I am interested in how nutrition underpins human health and in particular in relation to interactions with infections, other conditions like sickle cell disease and maternal and child health. My research aims to provide an evidence base to support nutrition-based interventions to improve health outcomes in populations in low and middle income countries.
Current ongoing studies are summarized below:
Nutrition and TB
I am leading research on nutrition and diabetes in TB patients in the Philippines in both inpatient and outpatient populations in Metro Manila, Cebu and Negros Occidental. I collaborate with investigators from San Lazaro Hospital, Manila, the Nutrition Centre, Philippines and the National TB programme.
Malnutrition in children
In Nepal I am leading research assessing malnutrition in pediatric admissions and outpatient clinics (children of all ages). In Cambodia, we are investigating the determinants of malnutrition of young children within the NHAM birth cohort, with a focus on infections and the microbiome. In Burundi we are collaborating with Action Against Hunger to evaluate malnutrition diagnosis and referral within the integrated community case based management programme (iCCM).
Nutrition as a modulator of sickle cell disease
Within the Muhimbili Sickle Cohort in Tanzania, my previous research has focused on nutritional and genetic modulation of sickle cell disease (SCD).

Disciplines

Epidemiology, Nutrition, Maternal and child health, infectious diseases

Other areas of interest

Nutrition and hypertension/vascular function and role of infections, interactions between diabetes and infections.

The country/countries where you work currently

The Philippines, Nepal, Bangladesh, Cambodia, UK, Japan, Tanzania, Kenya, The Gambia, India

Five MOST IMPORTANT/INTERESTING recent publications

  1. Lee N, Makani J, Tluway F, Makubi A, Armitage AE, Pasricha SR, Drakesmith A, Prentice AM & Cox SE. Decreased hepcidin levels are associated with low steady-state hemoglobin in children in the Muhimbili sickle cohort, Tanzania. EBioMed, 2018. In press
  2. Cox SE, Ellins EA, Marealle AI, Newton CR, Soka D, Sasi P, Di Tanna GL, Johnson W, Makani J, Prentice AM, Halcox JP & Kirkham FJ. Ready-to-use food supplement +/- arginine & citrulline with daily chloroquine in Tanzanian children with sickle cell disease: a double blind random order cross-over trial. Lancet Hematology, 2018 In press –
  3. Yamanashi H, Kulkarni B, Edwards T, Kinra S, Koyamatsu J, Nagayoshi M, Shimizu Y, Maeda T & Cox SE. Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan. Geriatrics & Gerontology International, in press –
  4. Marealle AI, Siervo M, Wassel S, Bluck L, Prentice AM, Minzi O, Sasi P, Kamuhabwa A, Soka D, Makani J, Cox SE. A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. Nitric Oxide. 2018 Jan 2;74:19-22. doi: 10.1016/j.niox.2017.12.009. [Epub ahead of print]
  5. Nkya S, Mgaya J, Urio F, Makubi A, Thein SL, Menzel S, Cox SE, Newton CR, Kirkham FJ, Mmbando BP, Makani J. Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania. EBioMedicine. 2017 Sep;23:146-149. doi: 10.1016/j.ebiom.2017.08.006. Epub 2017 Aug 8.

Link to all publications

http://www.ncbi.nlm.nih.gov/sites/myncbi/1tmZEPnoXym/bibliography/40021911/public/?sort=date&direction=decendinga

Message

I propose that nutrition is one of the most important modifiable environmental factors underlying health and disease. Along with infections such as malaria, nutrition has been one of the strongest selection pressures over our recent evolutionary history. This has significant implications in relation to the rapid changes in diet and lifestyle that are occurring globally. Under and over-nutrition are increasingly occurring within the same population groups and in both low and high-income countries.

Nutrition is essential to consider at individual and community/population levels in order to ensure that health interventions are optimally successful.

My research focuses on understanding the mechanisms by which nutritional factors affect health outcomes, with a focus on low- and middle-income country settings and encompassing infectious and non-infectious disease processes.

Professor Juntra Karbwang Laothavorn

    COURSES: YEAR:

Qualifications

MD, DTM&H, PhD

Research gate or Linked-in account links

https://www.researchgate.net/profile/Juntra_Karbwang

Affiliation(s)

  • Thammasat University, Bangkok, Thailand
  • FERCAP, Bangkok, Thailand

Background

  • Juntra Karbwang Laothavorn MD, DTM&H, PhD has been a part of the Institution of Tropical Medicine, Nagasaki University, as Professor and Head of Clinical Product Development Department since April, 2012.  Her responsibility is to develop a mechanism and system for NEKKEN Clinical Health Product (drug/vaccine) development.
  • Prior to joining NEKKEN, she spent 14 years (1998-2012) at the World Health Organization’s Special Program on Tropical Disease Research (WHO/TDR) in Geneva, Switzerland.  She has produced a series of Standard Operating Procedures for WHO/TDR clinical investigators and clinical monitors, and coordinated the production of WHO Operational Guidelines for Ethics Committees That Review Biomedical Research (translated into more than 20 languages).
  • She spent 17 years (1981-1998) at the Tropical Research Institute, Mahidol University in Bangkok, Thailand.  Her last appointment was Professor of Clinical Tropical Medicine and Head of Clinical Tropical Pharmacology Unit.  Her academic research was concentrated on the Clinical Pharmacology of antimalarials.  She has published more than 140 original articles widely on clinical development of drugs for Tropical Diseases.

Teaching

  • Co-director of Conducting Responsible Research for TMGH
  • Course director for Clinical Tropical Pharmacology at the Institution of Tropical Medicine, Mahidol University, Bangkok, Thailand  (1981-1998)
  • Developed training curricula for clinical monitors, clinical investigators and members of ethics committee in African and Asian countries (1998-2012).
  • Developed curriculum for short training course in Product Research and Development in 2005 and teach annually on one module in good clinical practice at NEKKEN.

Research

  • Development of innovative method for enhanced informed consent form in clinical research (supported by WHO/TDR)
  • Assessment of the quality of Ethical Review for Clinical Research in Asia (Supported by WHO/TDR and FERCAP – www. FERCAP-SIDCER.org)
  • Development of Shiunko ointment for Cutaneous Leishmaniasis
  • Development of Khod Kamoa (herbal medicine) for Cholangiocarcinoma (in collaboration with Thammasat university and the Thai Government Pharmaceutical Organization)

The country/countries where you work currently

  • China
  • Korea
  • Taiwan
  • Bhutan
  • India
  • Indonesia
  • Philippines
  • Thailand
  • Malaysia
  • Sri Lanka
  • Ethiopia

Five MOST IMPORTANT/INTERESTING recent publications

  1. Nut Koonrungsesomboon, Supanimit Teekachunhatean, Nutthiya Hanprasertpong, Junjira Laothavorn, Kesara Na-Bangchang & Juntra Karbwang (2016).  Improved participants’ understanding in a healthy volunteer study using the SIDCER informed consent form:a randomized-controlled study.  Dur J Clin Pharmacol 72:413-421
  2. Kesara Na-Bangchang,  Oumer Ahmed,  Jemal Hussein, Kenji Hirayama, Panida Kongjam,  Abraham Aseffa,  and Juntra Karbwang (2016).  Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis  Evidence-Based Complementary and Alternative Medicine http://dx.doi.org/10.1155/2016/5984709
  3. Nut Koonrungsesomboon, Kesara Na-Bangchang, Juntra Karbwang. (2014) Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pacific Journal of Tropical Medicine, 412-420 Doi:10.1016/s1995-7645(14)60069-9
  4. Tullayakorn Plengsuriyakarn, Veerachai Thitapakorn, Kesara Na-Bangchang, Juntra Karbwang (2013). Thai Medicinal plants: Potential sources of anticholangiocarcinoma drugs. International Journal of Pharmacy and Pharmacology. 2(5), 068-082
  5. Juntra Karbwang and Kesara NaBangchang (2013) Practical Application of International Standards and Guidelines to Address Ethical Challenges in Clinical Trials. J Clinical Res Bioeth 4: 144. doi:10.4172/2155-9627.1000144

Message

Conducting responsible research is more than the desire to do the right thing. It is crucial that students recognize and appreciate the wide range of good practices in conducting research and publication. It is important that the students act responsibly to these standards throughout research processes. This training course addresses the topics of responsible research, good research practice, standards for development of protocol, data management and publication of research results. The training will elaborate required acceptable practices for achieving excellence in research across all fields and disciplines. The lectures will be complemented by examples and exercises, so that students have opportunities to apply the principles into practices.

Professor Noriyuki Nishida

    COURSES: YEAR:

Qualifications

MD.PhD.

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/mmi/cmb/index_e.html

Background

We focus on I was born in Fukuoka, Japan 1965, and studied medicine at Ryukyu University School of Medicine. I have studied about most mysterious infectious agent, prion, since 1995 in Japan, France, and US. From 2009, I am leading my team as a professor in Nagasaki University Graduate School of Biomedical Sciences.

Teaching

Molecular medicine about prion diseases

Research

  • We focus on drug-discovery for prion diseases, developing a new diagnostic method, analysis of host-pathogen relationship, and autophagy.
  • Collaborating with research group of neurosurgeons, we are studying the possibility of the stem-cell transplantation for neurological disorders too.
  • Recently, we have developed a new in vitro amplifying method of PrPSc (real-time Quaking Induce Conversion: RT-QuIC). We applied this amplification technique to detect small amounts of PrPSc in patient’s CSF and established as a diagnostic test of human prion diseases.

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Hanae Takatsuki, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Takehiro Nakagaki, Tsuyoshi Mori, Daisuke Ishibashi, Ban Mihara, Masaki Takao, Yasushi Iwasaki, Mari Yoshida, Ryuichiro Atarashi, Noriyuki NishidaRapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS ONE 06/2015; 10(6):e0126930. DOI:10.1371/journal.pone.0126930
  2. Kazunori Sano, Ryuichiro Atarashi, Daisuke Ishibashi, Takehiro Nakagaki, Katsuya Satoh, Noriyuki NishidaConformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion. Journal of Virology 07/2014; 88(20). DOI:10.1128/JVI.00585-14
  3. Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, Ryuichiro Atarashi: FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy 06/2013; 9(9). DOI:10.4161/auto.25381
  4. Daisuke Ishibashi, Ryuichiro Atarashi, Takayuki Fuse, Takehiro Nakagaki, Naohiro Yamaguchi, Katsuya Satoh, Kenya Honda, Noriyuki Nishida: Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection. Journal of Virology 02/2012; 86(9):4947-55. DOI:10.1128/JVI.06326-11
  5. Ryuichiro Atarashi, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Naohiro Yamaguchi, Daisuke Ishibashi, Takehiro Matsubara, Takehiro Nakagaki, Hitoki Yamanaka, Susumu Shirabe, Masahito Yamada, Hidehiro Mizusawa, Tetsuyuki Kitamoto, Genevieve Klug, Amelia McGlade, Steven J Collins, Noriyuki Nishida: Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nature medicine 02/2011; 17(2):175-8. DOI:10.1038/nm.2294

Message

I specialize in prion disease, a 100% fatal infectious disease, which is said to be the most miserable disease for humankind. Prion encompasses various aspects including infectious protein, pathogens without genes, contagious dementia, amyloidosis, and zoonosis, which require cross-sectoral research approaches. The development of BSE relates to the problems of food safety, and many people may still remember this disease causing international issues in terms of import control. In the lectures, I plan to examine the meaning of the existence of “infectious protein” in pathogenic microorganisms through discussion, while learning the history of prion discovery and identification of the pathogen.

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