Faculty

Professor Noriyuki Nishida

Speciality / Research theme / Keywords
Virology(Prion)
Programme director
Masters Programme

Qualifications

MD.PhD.

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/mmi/cmb/index_e.html

Background

We focus on I was born in Fukuoka, Japan 1965, and studied medicine at Ryukyu University School of Medicine. I have studied about most mysterious infectious agent, prion, since 1995 in Japan, France, and US. From 2009, I am leading my team as a professor in Nagasaki University Graduate School of Biomedical Sciences.

Teaching

Molecular medicine about prion diseases

Research

  • We focus on drug-discovery for prion diseases, developing a new diagnostic method, analysis of host-pathogen relationship, and autophagy.
  • Collaborating with research group of neurosurgeons, we are studying the possibility of the stem-cell transplantation for neurological disorders too.
  • Recently, we have developed a new in vitro amplifying method of PrPSc (real-time Quaking Induce Conversion: RT-QuIC). We applied this amplification technique to detect small amounts of PrPSc in patient’s CSF and established as a diagnostic test of human prion diseases.

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Hanae Takatsuki, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Takehiro Nakagaki, Tsuyoshi Mori, Daisuke Ishibashi, Ban Mihara, Masaki Takao, Yasushi Iwasaki, Mari Yoshida, Ryuichiro Atarashi, Noriyuki NishidaRapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS ONE 06/2015; 10(6):e0126930. DOI:10.1371/journal.pone.0126930
  2. Kazunori Sano, Ryuichiro Atarashi, Daisuke Ishibashi, Takehiro Nakagaki, Katsuya Satoh, Noriyuki NishidaConformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion. Journal of Virology 07/2014; 88(20). DOI:10.1128/JVI.00585-14
  3. Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, Ryuichiro Atarashi: FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy 06/2013; 9(9). DOI:10.4161/auto.25381
  4. Daisuke Ishibashi, Ryuichiro Atarashi, Takayuki Fuse, Takehiro Nakagaki, Naohiro Yamaguchi, Katsuya Satoh, Kenya Honda, Noriyuki Nishida: Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection. Journal of Virology 02/2012; 86(9):4947-55. DOI:10.1128/JVI.06326-11
  5. Ryuichiro Atarashi, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Naohiro Yamaguchi, Daisuke Ishibashi, Takehiro Matsubara, Takehiro Nakagaki, Hitoki Yamanaka, Susumu Shirabe, Masahito Yamada, Hidehiro Mizusawa, Tetsuyuki Kitamoto, Genevieve Klug, Amelia McGlade, Steven J Collins, Noriyuki Nishida: Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nature medicine 02/2011; 17(2):175-8. DOI:10.1038/nm.2294

Message

I specialize in prion disease, a 100% fatal infectious disease, which is said to be the most miserable disease for humankind. Prion encompasses various aspects including infectious protein, pathogens without genes, contagious dementia, amyloidosis, and zoonosis, which require cross-sectoral research approaches. The development of BSE relates to the problems of food safety, and many people may still remember this disease causing international issues in terms of import control. In the lectures, I plan to examine the meaning of the existence of “infectious protein” in pathogenic microorganisms through discussion, while learning the history of prion discovery and identification of the pathogen.

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