教員紹介

西田 教行教授

専門・研究テーマ・キーワード
ウイルス学(プリオン)
担当課程
博士前期課程専任教員

取得学位・資格

MD.PhD.

個人/所属ウェブページ

http://www.med.nagasaki-u.ac.jp/mmi/cmb/index_e.html

経歴

We focus on I was born in Fukuoka, Japan 1965, and studied medicine at Ryukyu University School of Medicine. I have studied about most mysterious infectious agent, prion, since 1995 in Japan, France, and US. From 2009, I am leading my team as a professor in Nagasaki University Graduate School of Biomedical Sciences.

教育活動

Molecular medicine about prion diseases

研究活動

  • We focus on drug-discovery for prion diseases, developing a new diagnostic method, analysis of host-pathogen relationship, and autophagy.
  • Collaborating with research group of neurosurgeons, we are studying the possibility of the stem-cell transplantation for neurological disorders too.
  • Recently, we have developed a new in vitro amplifying method of PrPSc (real-time Quaking Induce Conversion: RT-QuIC). We applied this amplification technique to detect small amounts of PrPSc in patient’s CSF and established as a diagnostic test of human prion diseases.

現在の主な研究活動地域

Japan

最近の5つの出版物

  1. Hanae Takatsuki, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Takehiro Nakagaki, Tsuyoshi Mori, Daisuke Ishibashi, Ban Mihara, Masaki Takao, Yasushi Iwasaki, Mari Yoshida, Ryuichiro Atarashi, Noriyuki NishidaRapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS ONE 06/2015; 10(6):e0126930. DOI:10.1371/journal.pone.0126930
  2. Kazunori Sano, Ryuichiro Atarashi, Daisuke Ishibashi, Takehiro Nakagaki, Katsuya Satoh, Noriyuki NishidaConformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion. Journal of Virology 07/2014; 88(20). DOI:10.1128/JVI.00585-14
  3. Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, Ryuichiro Atarashi: FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy 06/2013; 9(9). DOI:10.4161/auto.25381
  4. Daisuke Ishibashi, Ryuichiro Atarashi, Takayuki Fuse, Takehiro Nakagaki, Naohiro Yamaguchi, Katsuya Satoh, Kenya Honda, Noriyuki Nishida: Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection. Journal of Virology 02/2012; 86(9):4947-55. DOI:10.1128/JVI.06326-11
  5. Ryuichiro Atarashi, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Naohiro Yamaguchi, Daisuke Ishibashi, Takehiro Matsubara, Takehiro Nakagaki, Hitoki Yamanaka, Susumu Shirabe, Masahito Yamada, Hidehiro Mizusawa, Tetsuyuki Kitamoto, Genevieve Klug, Amelia McGlade, Steven J Collins, Noriyuki Nishida: Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nature medicine 02/2011; 17(2):175-8. DOI:10.1038/nm.2294

メッセージ

人類にとって最も悲惨な病とも言われる100%致死性の感染症,プリオン病を専門に研究しています。感染するたんぱく質,遺伝子のない病原体,うつる認知症,アミトイドーシス,人獣共通感染症,とプリオンはいろんな顔を持ち,そのため分野横断的な研究アプローチが必要となる。BSE発生は食の安全に関わる問題であり,国際的な輸入規制問題に発展したことは覚えている人も多いかもしれません。授業では,プリオン病発見の歴史や病原体を同定するまでの道のりを学びながら,病原微生物界における「感染するたんぱく質」の存在意味などを考え,みなさんとディスカッションをしていきたいと考えています。

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