Faculty

Professor Moi Meng Ling

Speciality / Research theme / Keywords
Virology, Infection Immunology
Programme director
Masters Programme

Qualifications

B.Sc., M.Sc., Ph.D.

Personal/work Web page addresses

https://sites.google.com/site/moisherrye/
http://www.tm.nagasaki-u.ac.jp/nekken/english/research/virology.html

Research gate or Linked-in account links

https://researchmap.jp/sherrymoi/?lang=english

Affiliation(s)

  • Institute of Tropical Medicine, Nagasaki University
  • National Institute of Infectious Diseases, Japan
  •  Japanese Society of Virology, Japanese Society of Tropical Medicine, Japanese Society of Infectious Disease

Background

2020-present Professor, Institute of Tropical Medicine, Nagasaki University
2015-2019 Associate Professor, Institute of Tropical Medicine, Nagasaki University
2015-present Deputy Director, WHO Collaboration Center for Research and Reference of Tropical Viral Diseases
2015-2014 Research Collaborator, National Institute of Infectious Diseases
2010-2014 National Institute of Infectious Diseases, Researcher
2006-2010 National Institute of Infectious Diseases, Ph.D. attachment program
2006-2010 Tsukuba University (Ph.D. in Medical Sciences)
2004-2006 Tsukuba University (M.Sc. in Medical Sciences)
2003-2004 Tsukuba University (Japanese language and Culture studies)
1999-2002 Universiti Putra Malaysia (B.Sc. in Microbiology, First Class Honours)

Teaching

Lectures on Virology and infection immunity, Ph.D. and M.Sc. graduate research

Research

I have been working on researches on prevention measures of arthropod-borne viral diseases, particularly on dengue. My primary research goals are directed toward understanding the basis of the development of an effective vaccine for prevention measures against dengue fever. My previous projects have led to the successful development of in vitro and in vivo models for the dengue vaccine evaluation studies. The novel models have also lead to a better understanding of the immune responses induced after dengue vaccination and infection. Using these novel tools, my future plans are aimed at developing an effective and safe dengue vaccine, to contribute to the reduction of dengue disease burden worldwide.
Research activities of our group, Department of Virology, Institute of Tropical Medicine are as follows:
Field epidemiology on arthropod borne diseases in Vietnam, Myanmar, Philippines, Kenya, Nepal, Malaysia, Sri Lanka.
Vaccine and therapeutic development against dengue and other arthropod-borne diseases
Identification of factor(s) involved in the pathogenesis of dengue and other arthropod-borne diseases
Development of rapid diagnostics for dengue and other arthropod-borne diseases

The country/countries where you work currently

  • Japan
  • Vietnam
  • Philippines
  • Myanmar
  • Malaysia

Five MOST IMPORTANT/INTERESTING recent publications

  1. Bui TT, et al. A single amino acid substitution in the NS4B protein of Dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response. J Gen Virol. 2018 Aug;99(8):1044-1057.
  2. Ly MHP, et al. Dengue virus infection-enhancement activity in neutralizing antibodies of healthy adults before dengue season as determined by using FcγR-expressing cells. BMC Infect Dis. 2018 Jan 10;18(1):31
  3. Moi ML et al. Zika virus infection and microcephaly in Vietnam. Lancet Infect Dis. 2017 Aug;17(8):805-806.
  4. Moi ML et al. Marmosets (Callithrix jacchus) as a non-human primate model for evaluation of candidate dengue vaccines: induction and maintenance of specific protective immunity against challenges with clinical isolates. J Gen Virol. 2017 Dec;98(12):2955-2967.
  5. Moi ML et al. Human antibody response to dengue virus: implications for dengue vaccine design. Trop Med Health. 2016 Mar 14;44:1.

Message

With rapid globalization and changes in the population dynamics, health problems in tropical regions is changing and diversifying profoundly. Innovative measures are therefore needed to enable solutions to meet rapidly evolving needs and to provide new perspectives to develop effective control measures. In the recent decades, we have seen a surge of global infectious disease epidemics- there is an increasing need for cross-sector and collaborative efforts between different fields to rapidly address challenges and introducing effective control measures. Basic research addressing pathogenicity remains key in developing effective measures, including therapeutics and vaccines. For this reason, our research aims to bring together basic virology reach, from bench to the field, in collaboration with multinational researchers from diverse disciplinary, to explore on innovative solutions against dengue and other arthropod borne diseases.
Here, we would like to engage with students on educational and research activities in the development of effective strategies against major infectious diseases of global public health threat.

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