Faculty

Professor Katsuyuki Yui

Speciality / Research theme / Keywords
Immunology
Programme director
Masters ProgrammeDoctoral Programme

Qualifications

M.D., Ph.D.

Personal/work Web page addresses

http://www.med.nagasaki-u.ac.jp/mmi/im/

Affiliation(s)

Division of Immunology, Department of Microbiology and Immunology, Graduate School of Biomedical Sciences

Background

Education

  • 1975-81    Shinshu Univ. Sch. Med.
  • 1981-85    Graduate School of Medicine, Ph.D.

Work

  • 1985-88    Postdoctoral fellow, Dept. Pathology and Laboratory Medicine, Univ. Pennsylvania
  • 1988         Research Associate. Dept. Pathology & Laboratory Medicine, Univ. Pennsylvania
  • 1989-95    Research Assistant Professor, Dept. Pathology & Laboratory Medicine, Univ. Pennsylvania
  • 1995-97        Assistant Professor, Dept. Medical Zoology, Nagasaki University
  • 1997-2002    Professor, Dept. Medical Zoology & Immunology, Nagasaki University
  • 2002-pres.    Professor, Division of Immunology, Dept. Molecular  Microbiology and Immunology, Nagasaki University

Teaching

Immunology of Infectious diseases

Research

  • The immune system is a powerful defense which protects the host against invasion, growth, and division of the infectious organisms that come from the outside environment. It consists two major systems: innate immunity, which constitutively protects the host against the invasion of microorganisms, and adaptive immunity, which is a highly developed system and can specifically recognize micro-organisms and memorize them. These immune mechanisms co-evolved with the micro-organisms that invade them.
  • Our laboratory works mainly on the T cell-mediated adaptive immune system against infection with malaria parasites.  When infection by malaria parasites, the immune system is modulated, and protection is perturbed, which may be required to prevent damage to the hot due to excessive immune responses.  We have found a novel mechanism of immune regulation during infection by malaria parasites.  Our laboratory is also working on intravital imaging of immune cells during infection by malaria parasites, which enables us to directly visualize the interaction between parasites and the host’s immune system.

The country/countries where you work currently

Japan

Five MOST IMPORTANT/INTERESTING recent publications

  1. Kimura, D, Miyakoda, M., Kimura K., Honma, K., Hara, H., Yoshida, H., Yui, K.., Interleukin-27-producing CD4+ T cells regulate protective immunity during malaria parasite infection, Immunity, 44: 672-682, 2016.
  2. Akbari, M., Honma, K, Kimura, D., Miyakoda, M., Kimura,K, MatsuyamaT., Yui, K., IRF4 in dendritic cells inhibits IL-12 and controls Th1 immune responses against Leishmania major. J. Immunol., 192 (5): 2271-2279. 2014.
  3. Kimura, K., Kimura, D., Matsushima, Y., Miyakoda, M., Honma, K., Yuda, M., Yui, K., CD8+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection, Inf. Immun. 81 (10) : 3825-3834. 2013.
  4. Closeup: Cross-presentation of malaria antigen by brain microvessels: why CD8+ T cells are critical for the pathogenesis of cerebral malaria.  EMBO Mol. Med. 5 (7):899-901、2013.
  5. Development of memory CD8+ T cells and their recall responses during blood-stage infection with    Plasmodium berghei ANKA. J. Immunol., 189(9):4396-4404. 2012.

Message

Immunology is an important subject in order to understand infectious diseases. One of the biggest achievements in immunology is the development of vaccines, which save millions of people. However, vaccines have not been developed for all infectious diseases. In particular, vaccine development is difficult in chronic infectious diseases such as HIV, tuberculosis, and malaria, all of which are major infectious diseases in tropical regions. You need to understand what makes vaccine development difficult. I look forward to discussing and thinking about these problems together with you.

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